Composites of Enteric Polymer/Magnetite: Preparation and Application in Release Processes
DOI:
https://doi.org/10.6000/1929-5030.2012.01.02.3Keywords:
Controlled release, magnetite, fluorescenceAbstract
The controlled release of drugs represents an interesting procedure applied in the minimization of side effects and in the therapeutic action of pharmacological molecules. With the aim of measuring the kinetics of release of aspirin dispersed in composite of an enteric polymer (Eudragit L-100) in the presence/absence of magnetic particles, we have considered the measurement of fluorescence as a convenient tool. The results indicate that rate of release and amount of dispersed drug in solution varies directly with the concentration of magnetite in the composite, as a consequence of strong interaction between components of microparticles.
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[22] Gonzalez M, Galano A, Rieumont J, Lopez T, Dupeyron D, Albaran L. Drug-Matrix Interactions in Nanostructured Materials Containing Acetyl Salicylic Acid Using an Enteric Polymer As a Coating. J Phys Chem C 2008; 112: 20222-6. http://dx.doi.org/10.1021/jp806572g
[2] Wada M, Nishiwaki J, Yamane T, Ohwaki Y, Aboul-Enein HY, Nakashima K. Interaction study of aspirin or clopidogrel on pharmacokinetics of donepezil hydrochloride in rats by HPLC-fluorescence detection. Biomed Chromatogr 2007; 21: 616-20. http://dx.doi.org/10.1002/bmc.794
[3] Byun HS, Youn YN, Yun YH, Yoon SD. Selective separation of aspirin using molecularly imprinted polymers. Sep Purif Technol 2010; 74: 144-53. http://dx.doi.org/10.1016/j.seppur.2010.05.017
[4] Curini R, D'Ascenzo G, Fraioli A, Gentili A, Girelli G, Orru MA, Materazzi S. Analusis 1999; 27: 786-94. http://dx.doi.org/10.1051/analusis:1999145
[5] Shadick NA, Karlson EW, Cook NR, Maher NE, Buring JE, Lee IM. Low-Dose Aspirin in the Primary Prevention of Rheumatoid Arthritis: The Women's Health Study. Arthitris Care Res 2010; 62: 545-50. http://dx.doi.org/10.1002/acr.20042
[6] Hawkey CJ. Nonsteroidal anti-inflammatory drug gastropathy. Gastroenterology 2000; 119: 521-35. http://dx.doi.org/10.1053/gast.2000.9561
[7] Allison MC, Howatson AG, Torrance CJ, Lee FD, Russell RI. Gastrointestinal Damage Associated with the Use of Nonsteroidal Antiinflammatory Drugs. N Engl J Med 1992; 327: 749-54. http://dx.doi.org/10.1056/NEJM199209103271101
[8] Wolfe MM, Lichtenstein DR, Singh G. Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 1999; 340: 1888-99. http://dx.doi.org/10.1056/NEJM199906173402407
[9] Rich M, Scheiman JM. Nonsteroidal anti-inflammatory drug gastropathy at the new millennium: Mechanisms and prevention. Semin Arthritis Rheum 2000; 30: 167-79. http://dx.doi.org/10.1053/sarh.2000.16643
[10] Zeng P, Kline TL, Wang JP, Wiedmann TS. Thermal response of superparamagnetic particles suspended in liquid and solid media. J Magn Magn Mater 2009; 321: 373-6. http://dx.doi.org/10.1016/j.jmmm.2008.09.032
[11] Zhou LL, Yuan JY, Yuan WZ, Sui XF, Wu SZ, Li ZL, et al. Synthesis, characterization, and controllable drug release of pH-sensitive hybrid magnetic nanoparticles. J Magn Magn Mater 2009; 321: 2799-804. http://dx.doi.org/10.1016/j.jmmm.2009.04.020
[12] Zavisova V, Koneracka M, Muckova M, Kopcansky P, Tomasovicova N, Lancz G, et al. Synthesis and characterization of polymeric nanospheres loaded with the anticancer drug paclitaxel and magnetic particles. J Magn Magn Mater 2009; 321: 1613-36. http://dx.doi.org/10.1016/j.jmmm.2009.02.097
[13] Liu TY, Hu SH, Liu KH, Liu DM, Chen SY. Preparation and characterization of smart magnetic hydrogels and its use for drug release. J Magn Magn Mater 2006; 304: E397-9. http://dx.doi.org/10.1016/j.jmmm.2006.01.203
[14] Huang LY, Yang MC. Behaviors of controlled drug release of magnetic-gelatin hydrogel coated stainless steel for drugeluting-stents application. J Magn Magn Mater 2007; 310: 2874-6. http://dx.doi.org/10.1016/j.jmmm.2006.11.151
[15] de Oliveira HP, Tavares GF, Nogueiras C, Rieumont J. Physico-chemical analysis of metronidazole encapsulation processes in Eudragit copolymers and their blending with amphiphilic block copolymers. Int J Pharm 2009; 380: 55-61. http://dx.doi.org/10.1016/j.ijpharm.2009.06.028
[16] de Oliveira HP, Albuquerque JJF, Nogueiras C, Rieumont J. Physical chemistry behavior of enteric polymer in drug release systems. Int J Pharm 2009; 366: 185-9. http://dx.doi.org/10.1016/j.ijpharm.2008.08.041
[17] Sun J, Zhou SB, Hou P, Yang Y, Weng J, Li XH, et al. Synthesis and characterization of biocompatible Fe3O4 nanoparticles. J Biomed Mater Res 2007; 80A: 333-41. http://dx.doi.org/10.1002/jbm.a.30909
[18] Jain KB, Morales MA, Sahoo SK, Leislie-Pelecky DL, Labhasetwar V. Iron oxide nanoparticles for sustained delivery of anticancer agents. Mol Pharmaceutics 2005; 2: 194-205. http://dx.doi.org/10.1021/mp0500014
[19] Venema DP, Hollaman Peter CH, Janssen Karin PLTM, Katan MB. Determination of acetylsalicylic acid and salicylic acid in foods, using HPLC with fluorescence detection. J Agric Food Chem 1996; 44: 1762-1767. http://dx.doi.org/10.1021/jf950458y
[20] Lin SY, Liao CM, Hsiue GH. A Reflectance Ftir/Dsc Microspectroscopic Study of the Nonisothermal Kinetics of Anhydride Formation in Eudragit L-100 Films. Polym Degrad Stab 1995; 47: 299-303. http://dx.doi.org/10.1016/0141-3910(94)00129-V
[21] Zaroni M, Ramos DT, Murakami FS, Carvalho MAS, Janissek PR, Andreazza IF, et al. Thermal behavior and interaction studies of theophylline with various excipients. Lat Am J Pharm 2008; 27: 191-6.
[22] Gonzalez M, Galano A, Rieumont J, Lopez T, Dupeyron D, Albaran L. Drug-Matrix Interactions in Nanostructured Materials Containing Acetyl Salicylic Acid Using an Enteric Polymer As a Coating. J Phys Chem C 2008; 112: 20222-6. http://dx.doi.org/10.1021/jp806572g
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Published
2012-12-31
How to Cite
Lima, S. de, & Oliveira, H. de. (2012). Composites of Enteric Polymer/Magnetite: Preparation and Application in Release Processes. Journal of Applied Solution Chemistry and Modeling, 1(2), 94–99. https://doi.org/10.6000/1929-5030.2012.01.02.3
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