Solubility of Fudosteine in Some Pure and Mixed Solvents from (278.15 to 308.15) K
DOI:
https://doi.org/10.6000/1929-5030.2012.01.02.4Keywords:
Fudosteine, solubility, Apelblat equation, crystallizationAbstract
The solubility of fudosteine has been determined in pure methanol, ethanol, water and in mixed solvents of methanol + water and ethanol+ water over the temperature range of (278.15 to 308.15) K at atmosphere pressure. The solubility is high in water, lower in ethanol. In the binary mixtures, the solubility of fudosteine increases with increasing concentration of water. The solubility of fudosteine increases with increasing temperature. The temperature dependence on the solubility data was well-correlated with the modified Apelblat equation, which could be used as a useful model for the purification process of fudosteine.References
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[3] Takahashi K, Kai H, Mizuno H, Koda T, Miyata T. Effect of fudosteine, A new cysteine derivative, on mucociliary transport. J Pharm Pharmacol 2001; 53: 911-14. http://dx.doi.org/10.1211/0022357011776090
[4] Xu FQ, Zhang ZJ, Jiao HY, Tian Y, Zhang BB, Chen Y. Quantification of fudosteine in human plasma by highperformance liquid chromatography- electrospray ionization mass spectrometry employing precolumn derivatization with 9-fluorenylmethyl chloroformate. J Mass Spectrom 2006; 41: 685-92. http://dx.doi.org/10.1002/jms.1028
[5] Rhee CK, Kang CM, You MB, Yoon HK, Kim YK, Kim KH, et al. Effect of fudosteine on mucin production. Eur Respir J 2008; 32: 1195-202. http://dx.doi.org/10.1183/09031936.00018508
[6] Wen J, Wu YW, Zhang LL, Qi YP, Fan GR, Wu YT, et al. High-throughput determination of fudosteine in human plasma by liquid chromatography–tandem mass spectrometry, following protein precipitation in the 96-well plate format. J Chromatogr B 2008; 867: 153-59. http://dx.doi.org/10.1016/j.jchromb.2008.03.017
[7] Osoata GO, Hanazawa T, Brindicci C, Ito M, Barnes PJ, Kharitonov S, et al. Peroxynitrite Elevation in Exhaled Breath Condensate of COPD and Its Inhibition by Fudosteine. CHEST 2009; 135: 1513-20. http://dx.doi.org/10.1378/chest.08-2105
[8] Komatsu H, Yamaguchi S, Komorita N, Goto S, Takagi H, Ochi H, et al. Inhibition of endotoxin- and antigen-induced airway inflammation by fudosteine, a mucoactive agent. Pulm Pharmacol Ther 2005; 18: 121-27. http://dx.doi.org/10.1016/j.pupt.2004.11.002
[9] Itoh Y, Mizuno H. Expectorant Comprising Hydroxyalkylcysteine Derivative. U.S. Patent 5,047,428, Sep 10, 1991.
[10] Zuo WS, Xu JH. Solubility of Camellianin A in Methanol, Acetonitrile, Acetone, and Water from (283.2 to 313.2) K. J Chem Eng Data 2010; 55: 1372-73. http://dx.doi.org/10.1021/je900554r
[11] Peng B, Yan WD. Solubility of Luteolin in Ethanol + Water Mixed Solvents at Different Temperatures. J Chem Eng Data 2010; 55: 583-85. http://dx.doi.org/10.1021/je900381r
[12] Apelblata A, Manzurola E. Solubilities of o-aeetylsalicylic, 4- ami-nosalicylic, 3, 5-dinitrosalicylic, and P-toluic acid and magnesium-DL-aspartate in water from T = 278 to 348 K. J Chem Thermodyn 1999; 31: 85-91. http://dx.doi.org/10.1006/jcht.1998.0424
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Published
2012-12-31
How to Cite
Yan, F.-Y., Wang, M., Wen, J.-Y., Fu, Y., & Chen, L. (2012). Solubility of Fudosteine in Some Pure and Mixed Solvents from (278.15 to 308.15) K. Journal of Applied Solution Chemistry and Modeling, 1(2), 100–104. https://doi.org/10.6000/1929-5030.2012.01.02.4
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