Anticancer Activity of New Copper (II) Complexes with 6-Thiguanine Drug

Birjesh Singh; Jyotsna Mishra; K.S. Pitre; Alka Pradhan; Puspender Soni

doi:10.6000/1927-3037.2013.02.01.6

Authors

Birjesh Singh Department of Chemistry, MVM College, Bhopal 462008, (M.P), India
Jyotsna Mishra Department of Chemistry, Institute of Science and Technology, AISECT University, Bhopal (MP) India
K.S. Pitre Department of Chemistry, Dr. H.S. Gour University, Sagar (MP) India
Alka Pradhan Department of Chemistry, MVM College, Bhopal 462008, (M.P), India
Puspender Soni Department of Pharmacy, Globus Pharmacy college, Bhopal (MP) Indian

DOI:

https://doi.org/10.6000/1927-3037.2013.02.01.6

Keywords:

Cu (II) Complex, Polarography, Amperometry, Biological investigation, anticancer activity

Abstract

A new complex has been synthesized of Cu (II) complex with 6-thioguanine and phyico-chemical characterized by amperometry, polarography elemental analysis and FTIR spectroscopy. After Synthesis of metal complex, it was evaluated it for antibacterial and antifungal activities against various pathogenic microorganisms such as; Streptococcus aureus, Proteus. M., klebsiella pneumonia and Asperginus niger, Nigrosporan S.P. B16-F10 melanoma cell and C-57BL/6 mice has been used for anticancer screening of metal complex for in vitro and in vivo study. The result of pharmacological studies with M: L revealed that the complex is more potent as compared to the pure drug as regards to its anticancer activity.

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