Preschool Wheezing and Progress to Childhood Asthma
DOI:
https://doi.org/10.6000/1929-4247.2025.14.02.01Keywords:
Pediatric respiratory diseases, genetics, environmental factors, biomarkers, preventionAbstract
Aim: This narrative review aims to identify key elements that facilitate the transition from recurrent episodes of wheezing to chronic inflammatory airway disease.
Methods: The article presents the results of numerous studies that identify the influence of genetic and environmental factors on the development of asthma in children. Whole-genome data analysis revealed novel genetic loci associated with various asthma phenotypes. Additionally, the study underscored the significance of environmental factors, such as air pollution and microbial colonization, in the disease's onset.
Results: The results provided a foundation for developing new prevention and treatment strategies for childhood asthma, emphasizing a personalized approach that considers each patient's unique genetic and environmental profile. The main findings indicate that up to 50% of children under 6 years old experience wheezing episodes, but only 30% of these children develop asthma. Data analysis demonstrated that both genetic and environmental factors significantly influence asthma development in children with preschool wheezing. Genetic research has identified several genes associated with early-onset asthma, including CDHR3, IL33, and genes at the 17q12-21 locus. Surrounding conditions such as viral infections, allergens, tobacco smoke, and the microbiome also play a substantial role in asthma development.
Conclusions: Understanding the relationship between hereditary and environmental influences in the advancement from preschool wheeze to asthma is crucial for developing effective prophylactic and treatment strategies. The study of factors influencing the development of asthma in children is important for understanding the mechanisms of disease formation and developing effective methods of prevention and treatment. Special attention is paid to the interaction of genetic and external factors influencing the early stages of pathogenesis.
References
de Queiros VS, de França IM, Trybulski R, Vieira JG, dos Santos IK, Neto GR, et al. Myoelectric Activity and Fatigue in Low-Load Resistance Exercise with Different Pressure of Blood Flow Restriction: A Systematic Review and Meta-Analysis. Front Phys 2021; 12: 786752.
Trybulski R, Makar P, Alexe DI, Stanciu S, Piwowar R, Wilk M, et al. Post-Activation Performance Enhancement: Save Time with Active Intra-Complex Recovery Intervals. Front Phys 2022; 13: 840722.
World Health Organization. Asthma. 2020. https://www.who. int/news-room/facts-in-pictures/detail/asthma
Ayuk AC. Recurrent wheezing and asthma: Epidemiology and environmental determinants. Ped Pulmon 2023; 60(1): 54-6.
Vercelli D. From Amish farm dust to bacterial lysates: The long and winding road to protection from allergic disease. Sem Immunol 2023; 68: 101779.
Mirzakhmetova D, Kamkhen V, Akhmetzhanova Z, Sarmuldayeva S, Ayazbekov A, Iskakova F. Predictors associated with night sleep disturbance among breastfeeding women. Prevent Med 2024; 185: 108011.
Maulenkul T, Kuandyk A, Makhadiyeva D, Dautova A, Terzic M, Oshibayeva A, et al. Understanding the impact of endometriosis on women’s life: an integrative review of systematic reviews. BMC Wom Health 2024; 24(1): 524.
Dashi F, Seferi A, Rroji A, Enesi E, Petrela M. Bathing epilepsy: Report of three Caucasian cases. Acta Inf Med 2015; 23(2): 113-115.
Dobrovanov O, Dmytriiev D, Prochotsky A, Vidiscak M, Furkova K. Pain in COVID-19: Quis est culpa? Elect J Gen Med 2023; 20(1): em435.
Polatova DSh, Madaminov AYu, Savkin AV, Nurzhabov AI, Asamedinov NK, Ibragimova DA, et al. PD-L1 and p53 expression in squamous cell carcinoma of the oropharynx depending on human papilloma virus status. Opuh Gol Sei 2023; 13(2): 44-56.
Komilova N, Egamkulov K, Hamroyev M, Khalilova K, Zaynutdinova D. The impact of urban air pollution on human health. Med Persp 2023; 28(3): 170-179.
Ravshanov AX, Suhail M, Komilova N, Ravshanov S. Medical geographical zoning in part of Uzbekistan – A regional synthesis. Reg Sci Pol Pract 2024; 16(12): 100142.
Smiyan OI, Plakhuta VA, Bunda TP, Popov SV. Dynamics of cytokines in infants with acute obstructive bronchitis and thymomegalia. Lik Sprava Min Okhor Zdor Ukr 2015; (1-2): 81-85. https://pubmed.ncbi.nlm.nih.gov/26118033/
Dijk N, de Jongste JC, Postma DS, Koppelman GH. Genetics of onset of asthma. Cur Opin Allergy Clin Immunol 2013; 13(2): 193-202.
Stein MM, Thompson EE, Schoettler N, Helling BA, Magnaye KM, Stanhope C, et al. A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle. J Allergy Clin Immunol 2018; 142(3): 749-764.
Yang Z, Chen Z, Lin X, Yao S, Xian M, Ning X, et al. Rural environment reduces allergic inflammation by modulating the gut microbiota. Gut Microb 2022; 14(1): 2125733.
Xing Y, Leung AS, Wong GW. From preschool wheezing to asthma: Environmental determinants. Ped Allergy Immunol 2023; 34(11): e14049.
Papandreou D, Pavlidou E, Tyrovolas S, Mantzorou M, Andreou, E, Psara E, et al. Relation of maternal pre-pregnancy factors and childhood asthma: A cross-sectional survey in preschool children aged 2-5 years old. Medicina 2023; 59(1): 179.
Bloom CI, Franklin C, Bush A, Saglani S, Quint JK. Burden of preschool wheeze and progression to asthma in the UK: Population-based cohort 2007 to 2017. J Allerg and Clin Immunol 2021; 147(5): 1949-1958.
Bonato M, Bazzan E, Snijders D, Tinè M, Biondini D, Turato G, et al. Clinical and pathologic factors predicting future asthma in wheezing children. A longitudinal study. Americ J Resp Cell Molec Biol 2018; 59(4): 458-466.
Granell R, Curtin JA, Haider S, Kitaba NT, Mathie SA, Gregory LG, et al. A meta-analysis of genome-wide association studies of childhood wheezing phenotypes identifies ANXA1 as a susceptibility locus for persistent wheezing. eLife 2023; 12: e84315.
Andrenacci B, Ferrante G, Roberto G, Piacentini G, La Grutta S, Marseglia GL, Licari A. Challenges in uncontrolled asthma in pediatrics: Important considerations for the clinician. Exp Rev Clin Immunol 2022; 18(8): 807-821.
Bisgaard H, Nørgaard S, Sevelsted A, Chawes BL, Stokholm J, Mortensen EL, et al. Asthma-like symptoms in young children increase the risk of COPD. J Allerg Clin Immunol 2021; 147(2): 569-576.
Fitzpatrick AM, Huang M, Mohammad AF, Stephenson ST, Kamaleswaran R, Grunwell JR. Dysfunctional neutrophil type 1 interferon responses in preschool children with recurrent wheezing and IL-4-mediated aeroallergen sensitization. J Allerg Clin Immunol. Global 2024; 3(2): 100229.
Gaillard EA, Kuehni CE, Turner S, Goutaki M, Holden KA, de Jong CC, Lex C, et al. European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5-16 years. Europ Resp J 2021; 58(5): 2004173.
Kashanskiǐ SV, Zhetpisbaev BA, Il'derbaev OZ, Ermenbaǐ OT. Mesothelioma in the Republic of Kazakhstan: A review. Gig Sanit 2008; (5): 13-17. https://pubmed.ncbi.nlm.nih.gov/ 19069387/
Suwala S, Szulc P, Dudek A, Bialczyk A, Koperska K, Junik R. ChatGPT fails the Polish board certification examination in internal medicine: artificial intelligence still has much to learn. Pol Arch Int Med Pol Arch Med Wewnet 2023; 133(11).
Del Carpio-Delgado F, Romero-Carazas R, Pino-Espinoza GE, Villa-Ricapa LF, Núñez-Palacios EL, Aguilar-Cuevas MM, Espiritu-Martinez AP. Telemedicine in Latin America: a bibliometric analysis. EAI End Transact Perv Health Tech 2023; 9(1): 1-11.
Suwala S, Szulc P, Guzowski C, Kaminska B, Dorobiala J, Wojciechowska K, et al. ChatGPT-3.5 passes Poland's medical final examination-Is it possible for ChatGPT to become a doctor in Poland? Sage Open Med 2024; 12: 20503121241257777.
Spytska L. Global practice of reducing the level of tobacco consumption through legislative regulation. Med Law 2023; 42(2): 407-422.
Smith FM, Saglani S. Demystifying controversies in preschool wheeze. Exp Rev Resp Med 2023; 17(11): 1023-1031.
Ranjbar M, Whetstone CE, Omer H, Power L, Cusack RP, Gauvreau GM. The genetic factors of the airway epithelium associated with the pathology of asthma. Genes 2022; 13(10): 1870.
Lee SH, Lee PH, Kim BG, Seo HJ, Baek AR, Park JS, et al. Annexin A1 in plasma from patients with bronchial asthma: Its association with lung function. BMC Pulm Med 2018; 18(1): 1.
Kyvsgaard JN, Brustad N, Hesselberg LM, Vahman N, Thorsen J, Schoos AM, et al. Key risk factors of asthma-like symptoms are mediated through infection burden in early childhood. J Allerg Clin Immunol 2024; 153(3): 684-694.
Lee YJ, Fujisawa T, Kim CK. Biomarkers for recurrent wheezing and asthma in preschool children. Allergy Asthma Immunol Res 2019; 11(1): 16-28.
Lau HX, Chen Z, Van Bever H, Tham EH, Chan YH, Yap QV, et al. Clinical predictors of wheeze trajectories and associations with allergy in Asian children. An Allergy, Asthma & Immunol 2023; 131(4): 466-473.
García-Juárez HD, Bustamante-Ochoa C, del Carpio-Delgado F, Bravo-Chávez YM. PDCA methodology for improving process management in a natural products company. Aibi Rev Invest Admin Ing 2024; 12(1): 108-120.
Pleșca DA, Ionescu M, Dragănescu AC. Asthma prevention and recent advances in management. Glob Ped 2024; 9: 100209.
Gorbas VA, Smiyan OI, Kurhanska VO. Changes in the colon microflora of school-age children with bronchial asthma. New Arm Med J 2015; 9(3): 45-47.
Reddel HK, Bacharier LB, Bateman ED, Brightling CE, Brusselle GG, Buhl R, et al. Global initiative for asthma strategy 2021: Executive summary and rationale for key changes. Americ J Resp Critic Care Med 2022; 205(1): 17-35.
von Mutius E, Smits HH. Primary prevention of asthma: From risk and protective factors to targeted strategies for prevention. Lancet (London, Eng) 2020; 396(10254): 854-866.
Efremov A. Psychosomatics: Communication of the Central Nervous System through Connection to Tissues, Organs, and Cells. Clin Psychopharm Neurosci 2024; 22(4): 565-577.
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