Prevalence of Congenital Heart Defects and their Non-Inherited Risk Factors among Children through the Period 2019-2023: A Retrospective Comparative Study

Authors

DOI:

https://doi.org/10.6000/1929-4247.2024.13.03.8

Keywords:

Congenital, heart defects, risk factor, infant, children, prevalence

Abstract

Background: Congenital heart defects (CHD) are the most common types of congenital disabilities. The frequency of CHD among their patient populations also remains the leading cause of their increased mortality, accounting for an estimated 50% of all causes of death from abnormalities.

Objectives: The study aimed to identify the prevalence of non-inherited risk factors among children with cardiac defects and compare the prevalence of congenital heart defects among children in different governorates in Iraq related to non-inherited risk factors.

Materials and Methods: A retrospective study design was used to study congenital heart defects in children in Babylon Centre for Catheterization and Cardiac Surgery in Al-Imam Sadiq Hospital Babylon province, Iraq, from 15/10/2023 to 13/6/2024. A nonprobability convenience sample of 542 patients aged 0-18 years with CHD was collected by administering a constructed tool for the study. The data were collected from all Iraqi governorates, including the north, center, and south, as well as east and west countries.

Result: The study shows the mean age of children was 2.2 ±9.2 years. The majority of children included were within infant age groups, almost equal in their sexes, giving girl to boy, 1.04:1. The age at screening and diagnosis of Echo was more than half in the first month, and the type of defect was Ventricular-septal-defect (VSD) and Tetralogy of Fallot (TOF). The study findings show that there is a statistically significant relationship between risk factors related to maternal medication history, including Folic acid Supplements. Maternal diseases such as Rubella, with CHD, and the highest recorded governorates for congenital heart defects are Baghdad, Mosul, and Diyala.

Conclusions: The study concludes that most children included were within infant age groups, almost equal in their sexes, and the highest recorded governorates for congenital heart defects are Baghdad, Mosul, and Diyala. Also, the most frequent CHD is VSD and TOF, the history of maternal medication use, including folic acid supplements, and maternal diseases such as Rubella were significant factors in assessing the risk or outcome.

References

Zimmerman MS, Smith AGC, Sable CA, Echko MM, Wilner LB, Olsen HE, et al. Global, regional, and national burden of congenital heart disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet Child Adolesc Heal 2020; 4(3): 185-200. https://doi.org/10.1016/S2352-4642(19)30402-X DOI: https://doi.org/10.1016/S2352-4642(19)30402-X

Jemal S, Fentahun E, Oumer M, Muche A. Predictors of congenital anomalies among newborns in Arsi zone public hospitals, Southeast Ethiopia: a case-control study. Ital J Pediatr 2021; 47(1): 1-9. https://doi.org/10.1186/s13052-021-01093-6 DOI: https://doi.org/10.1186/s13052-021-01093-6

Walter HJJ, Moller JH. Pediatric Cardiology: The essential pocket guide [Internet]. Pediatric Cardiology: the essential Pocket guide 2014. Available from: https://linkinghub.elsevier.com/retrieve/pii/B9780702030642X0001X

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, et al. Heart Disease and Stroke Statistics - 2014 Update: A report from the American Heart Association. Vol. 129, Circulation 2014.

Ali FJAD, Hammood MD, Al-Dulaimy KM, Salman BM. Pattern of Congenital Heart Disease among Children Referred for Echocardiography in Ramadi City, West of Iraq. Al-Anbar Med J 2019; 15(2): 40-4. https://doi.org/10.33091/amj.2019.170901 DOI: https://doi.org/10.33091/amj.2019.170901

Naghavi-Behzad M, Alizadeh M, Azami S, Foroughifar S, Ghasempour-Dabbaghi K, Karzad N, et al. Risk Factors of Congenital Heart Diseases: A Case-Control Study in Northwest Iran. J Cardiovasc Thorac Res [Internet] 2013; 5(1): 5-9. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24251002%0 Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC3825379

Gilboa SM, Devine OJ, Kucik JE, Oster ME, Riehle-Colarusso T, Nembhard WN, et al. Congenital Heart Defects in the United States: Estimating the Magnitude of the Affected Population in 2010. Circulation 2016; 134(2): 101-9. https://doi.org/10.1161/CIRCULATIONAHA.115.019307 DOI: https://doi.org/10.1161/CIRCULATIONAHA.115.019307

Hospital IA nafees. Prevalence of Ventricular Septal Defect among Congenital Heart Defects in Prevalence of Ventricular Septal Defect among Congenital Heart Defects in Children attending Ibn Al-Nafees Hospital, 2018; (January 2015).

Ibrahim K, Emteres A, Al-stairway SA Raouf, Ali A, Samihamed M. Assessment of quality of life in congenital heart disease among Egyptian and Libyan children 2019; 1161: 782-90.

Khasawneh W, Hakim F, Abu Ras O, Hejazi Y, Abu-Aqoulah A. Incidence and Patterns of Congenital Heart Disease Among Jordanian Infants, a Cohort Study From a University Tertiary Center. Front Pediatr 2020; 8: 1-6. https://doi.org/10.3389/fped.2020.00219 DOI: https://doi.org/10.3389/fped.2020.00219

Majeed-Saidan MA, Atiyah M, Ammari AN, AlHashem AM, Rakaf MS, Shoukri MM, et al. Patterns, prevalence, risk factors, and survival of newborns with congenital heart defects in a Saudi population: a three-year, cohort case-control study. J Congenit Cardiol 2019; 3(1): 1-10. https://doi.org/10.1186/s40949-019-0023-8 DOI: https://doi.org/10.1186/s40949-019-0023-8

Zeineddine J, El Chamieh C, Bou Sanayeh E. The lack of specialized pediatric cardiac surgeons in Lebanon: a humanitarian catastrophe. Health Econ Rev [Internet] 2023; 13(1): 1-3. https://doi.org/10.1186/s13561-023-00424-z DOI: https://doi.org/10.1186/s13561-023-00424-z

Çaylan N, Yalçın SS, Tezel B, Üner O, Aydin Ş, Kara F. Evaluation of critical congenital heart disease from 2018 to 2020 in Turkey: A retrospective cohort study. BMC Pregnancy Childbirth 2023; 23(1): 1-11. https://doi.org/10.1186/s12884-023-06193-1 DOI: https://doi.org/10.1186/s12884-023-06193-1

Ryberg C. Children with Congenital Heart Defects Intellectual Functioning and Family Impact 2019.

Patel SS, Burns TL. Nongenetic risk factors and congenital heart defects. Pediatr Cardiol 2013; 34(7): 1535-55. https://doi.org/10.1007/s00246-013-0775-4 DOI: https://doi.org/10.1007/s00246-013-0775-4

Rehman Y, Wazir HD, Akbar A, Khan AM, Hussain I, Afridi A, et al. Congenital Heart Disease and Its Association in Children With Down Syndrome. Cureus 2022; 14(9). https://doi.org/10.7759/cureus.29176 DOI: https://doi.org/10.7759/cureus.29176

Alkaya DU, Öztürk B, Ülker AY, Bozlak S, Öztürk E, Dedeoğlu R, et al. Congenital Heart Defects and Outcome in a Large Cohort of Down Syndrome: A Single-Center Experience from Turkey. Turkish Arch Pediatr 2023; 58(5): 473-9.

Upadhyay J, Tiwari N, Rana M, Rana A, Durgapal S, Bisht S. Pathophysiology, etiology, and recent advancement in the treatment of congenital heart disease. J Indian Coll Cardiol 2019; 9(2): 67. https://doi.org/10.4103/JICC.JICC_11_19 DOI: https://doi.org/10.4103/JICC.JICC_11_19

Sun L, Wu Q, Wang H, Liu J, Shao Y, Xu R, et al. Maternal exposure to ambient air pollution and risk of congenital heart defects in Suzhou, China. Front Public Heal 2023; 10. https://doi.org/10.3389/fpubh.2022.1017644 DOI: https://doi.org/10.3389/fpubh.2022.1017644

Roy K, Humayun Shahed M, Roy K, Sahely Sarah Q, Sur Chowdhury N. Clinical Presentation and Complications of Different Congenital Heart Disease in Children. Am J Pediatr 2020; 6(4): 481. https://doi.org/10.11648/j.ajp.20200604.26 DOI: https://doi.org/10.11648/j.ajp.20200604.26

Munsi MAS, Sayeed MA, Akter M. Frequency and Pattern of Congenital Heart Defects in Infant of Diabetic Mother at Tertiary Care Hospital. Liaquat Natl J Prim Care 2023; 11(11): 3954-7. https://doi.org/10.18203/2320-6012.ijrms20233143 DOI: https://doi.org/10.18203/2320-6012.ijrms20233143

Helle E, Priest JR. Maternal obesity and diabetes mellitus as risk factors for congenital heart disease in the offspring. J Am Heart Assoc 2020; 9(8): 1-9. https://doi.org/10.1161/JAHA.119.011541 DOI: https://doi.org/10.1161/JAHA.119.011541

Lastivka I V., Pishak VP, Ryznychuk M, Khmara T V. Risk factor analysis for congenital heart defects in children. Regul Mech Biosyst 2020; 11(4): 524-30. https://doi.org/10.15421/022080 DOI: https://doi.org/10.15421/022080

Mao B, Qiu J, Zhao N, Shao Y, Dai W, He X, et al. Maternal folic acid supplementation and dietary folate intake and congenital heart defects. PLoS One 2017; 12(11): 1-14. https://doi.org/10.1371/journal.pone.0187996 DOI: https://doi.org/10.1371/journal.pone.0187996

Yanji Q, Shao L, Zhuang J, Bloom MS, Smith M, Nie Z, et al. First-trimester maternal folic acid supplementation reduced risks of severe and most congenital heart diseases in offspring: A large case-control study. J Am Heart Assoc 2020; 9(13). https://doi.org/10.1161/JAHA.119.015652 DOI: https://doi.org/10.1161/JAHA.119.015652

Qu Y, Lin S, Bloom MS, Wang X, Nie Z, Ou Y, et al. First-trimester maternal folic acid supplementation modifies the effects of risk factor exposures on congenital heart disease in offspring. Life 2021; 11(8): 1-14. https://doi.org/10.3390/life11080724 DOI: https://doi.org/10.3390/life11080724

Liu X, Liu G, Wang P, Huang Y, Liu E, Li D, et al. Prevalence of congenital heart disease and its related risk indicators among 90 796 Chinese infants aged less than 6 months in Tianjin. Int J Epidemiol 2015; 44(3): 884-93. https://doi.org/10.1093/ije/dyv107 DOI: https://doi.org/10.1093/ije/dyv107

Ye W, Deng X long, Children W, Huang S, Children W, Zhang T qiang. A multicenter case-control study on non-genetic risk factors in infants with congenital heart disease 2019; 1-11. https://doi.org/10.21203/rs.2.16559/v1 DOI: https://doi.org/10.21203/rs.2.16559/v1

Published

2024-09-24

How to Cite

Abd Ali, M. E. ., & Qasim, N. M. . (2024). Prevalence of Congenital Heart Defects and their Non-Inherited Risk Factors among Children through the Period 2019-2023: A Retrospective Comparative Study. International Journal of Child Health and Nutrition, 13(3), 192–199. https://doi.org/10.6000/1929-4247.2024.13.03.8

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General Articles