Use of Geometric Mean in Bioequivalence Trials

Authors

  • Abdur Rasheed Department of Research, Dow University of Health Sciences, Karachi, Pakistan
  • Afaq Ahmed Siddiqui Faculty of Pharmacy, University of Karachi, Pakistan

DOI:

https://doi.org/10.6000/1929-6029.2015.04.01.13

Keywords:

Geometric mean, Average bioequivalence, logarithmic transformation, Bioequivalence ranges, normal and log-normal distribution

Abstract

Bioequivalence data often do not follow the normality assumption on the linear (original) scale, therefore in that situation, the use of the logarithmic transformation is recommended. In the bioequivalence analysis, confusion arises about the use of geometric mean ratio when the logarithmic transformation is recommended by the regulatory authorities. The purpose of this research paper is to clear this confusion. Different average bioequivalence criteria are also reviewed in this paper.

Author Biographies

Abdur Rasheed, Department of Research, Dow University of Health Sciences, Karachi, Pakistan

Department of Research

Afaq Ahmed Siddiqui, Faculty of Pharmacy, University of Karachi, Pakistan

Faculty of Pharmacy

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Published

2015-01-27

How to Cite

Rasheed, A., & Siddiqui, A. A. (2015). Use of Geometric Mean in Bioequivalence Trials. International Journal of Statistics in Medical Research, 4(1), 114–120. https://doi.org/10.6000/1929-6029.2015.04.01.13

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General Articles