Theoretical Analysis on the Possible Interruption of Cell Division by Applying Physical Excitation to Gold Nanoparticles Introduced in Chromosomes
DOI:
https://doi.org/10.6000/1929-6037.2013.02.02.2Keywords:
Gold nanoparticles, cell membrane, chromosome, histone, ultrasound, electromagnetic wave, X-rayAbstract
Theoretical analysis on cell division control using physical excitations for biocompatible gold nanoparticles in chromosomes is performed. The methods of physical excitations are utilizing ultrasound, electromagnetic waves and X-rays. Due to the mass increase of chromosomes, ultrasound enhances the vibration of chromosomes in metaphase of mitosis, which will disturb the alignment of chromosomes on metaphase plates and will suppress cell divisions. Under the exposure of electromagnetic waves, gold wires composed of gold nanoparticles will act as antennas in chromosomes, which will absorb electromagnetic energy and increase the temperature of chromosomes. There is a possibility that the temperature rise will bring about the transformation of DNA structure and interrupt the mitosis process. Gold nanoparticles exposed by X-rays in chromosomes emit high energy electrons through photoelectric effect, which will bring about a possibility that the high energy electrons will break the DNA structure and suppress mitosis process.
References
Maeda H. Tumor-selective delivery of macromolecular drugs via EPR effect: Background and future prospects. Bioconjug Chem 2010; 21: 797. http://dx.doi.org/10.1021/bc100070g DOI: https://doi.org/10.1021/bc100070g
Naruse Y. Diffusion control of strongly correlated electrically conductive particles in liquid medium by applying graded electromagnetic fields, IEEJ transactions on electrical and electronic engineering, IEEJ Trans 2012, published online in Wiley Online Library (wileyonlinelibrary.com). DOI: https://doi.org/10.1002/tee.21772
Naruse Y. Mechanical vibration model for proteins and nanoparticles coupling with the cell membrane and its application to cell treatment. Japanese J Appl Phys 2004; 43: 3629. http://dx.doi.org/10.1143/JJAP.43.3629 DOI: https://doi.org/10.1143/JJAP.43.3629
Shenoy D, et al. Surface functionalization of gold nanoparticles using hetero-bifunctional poly(ethylene glycol)spacer for intracellular tracking and delivery. Int J Nanomed 2006; 1(1): 51-57. http://dx.doi.org/10.2147/nano.2006.1.1.51 DOI: https://doi.org/10.2147/nano.2006.1.1.51
Naruse Y. Mechanical vibration model for chromosomes in metaphase of mitosis and possible application to the interruption of cell division. BioSystems 2002; 66: 55-63. http://dx.doi.org/10.1016/S0303-2647(02)00033-3 DOI: https://doi.org/10.1016/S0303-2647(02)00033-3
Karp GC. Cell and Molecular Biology (Concepts and Experiments), 4th ed. John Wiley & Sons Inc, New York, USA 2005.
Naruse Y. Metal/amorphous silicon multilayer radiation detectors. IEEE Trans Nuclear Sci 1989; 36(2): 1347-52. http://dx.doi.org/10.1109/23.25528 DOI: https://doi.org/10.1109/23.25528
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