Alcohol Consumption in Patients with Psoriasis and its Relationship to Disease Severity
DOI:
https://doi.org/10.6000/1929-5634.2013.02.01.5Keywords:
, Alcohol consumption, psoriasis severity, Albania, alcohol biomarkers, raki consumptionAbstract
Moderate to severe psoriasis is associated with increased alcohol intake and excessive mortality from alcohol-related causes. Alcohol biomarkers are those providing an objective measurement of its consumption. The objective of this study is to assess alcohol consumption in a cohort of patients with psoriasis and to investigate the influence of alcohol intake on disease severity. Patients with psoriasis hospitalized at the Clinic of Dermatology, in Mother Teresa University Hospital were recruited in this cross- sectional study. Alcohol consumption was assessed via CAGE questionnaire and the self- reported amount of alcohol consumed, whereas disease severity was evaluated via PASI scoring system. Blood specimens were taken at admission and levels of gamma glutamyltransferase (GGT), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and mean corpuscular volume of erythrocytes (MCV) were measured. Statistical analysis was performed using SPSS 20.0 statistical package. A total of 62 in- patients completed the study. Significant correlations were observed between GGT and AST values with raki and beer consumption, ALT value with raki, beer and wine consumption and MCV value with raki consumption. Disease severity did not correlate significantly with raki and beer consumption (p> 0.05). Logistic regression analysis between Psoriasis Area and Severity Index (PASI) score and raki consumption in male patients with psoriasis duration of more than 3 years resulted in statistical significance (b= 23.5, p< 0.05). Combination of parameters related to chronic alcohol consumption offers advantage over every isolated test. Measurement of simple laboratory parameters combined with self- report methods of consumption allows identification of users.
References
McAleer MA, Mason DL, Cunningham S, et al. Alcohol misuse in patients with psoriasis: identification and relationship to disease severity and psychological distress. Br J Dermatol 2011; 164(6): 1256-61. http://dx.doi.org/10.1111/j.1365-2133.2011.10345.x DOI: https://doi.org/10.1111/j.1365-2133.2011.10345.x
Del Boca FK, Darkes J. The validity of self-reports of alcohol consumption: state of the science and challenges for research. Addiction 2003; (98 Suppl 2): 1-12. http://dx.doi.org/10.1046/j.1359-6357.2003.00586.x DOI: https://doi.org/10.1046/j.1359-6357.2003.00586.x
Alte D, Luedemann J, Rose HJ, John U. Laboratory markers carbohydrate-deficient transferrin, gamma-glutamyltransferase, and mean corpuscular volume are not useful as screening tools for high-risk drinking in the general population: results from the Study of Health in Pomerania (SHIP). Alcohol Clin Exp Res 2004; 28(6): 931-40. http://dx.doi.org/10.1097/01.ALC.0000128383.34605.16 DOI: https://doi.org/10.1097/01.ALC.0000128383.34605.16
Pietrzak A, Jastrzębska I, Chodorowska G, et al. Psoriasis and unreported excessive alcohol intake--a simple screening approach. J Eur Acad Dermatol Venereol 2011; 25(11): 1261-8. http://dx.doi.org/10.1111/j.1468-3083.2011.04101.x DOI: https://doi.org/10.1111/j.1468-3083.2011.04101.x
Wolf R, Wolf D, Ruocco V. Alcohol intake and psoriasis. Clin Dermatol 1999; 17: 423-30. http://dx.doi.org/10.1016/S0738-081X(99)00028-0 DOI: https://doi.org/10.1016/S0738-081X(99)00028-0
Gupta MA, Schork NJ, Gupta AK, Ellis CN. Alcohol intake and treatment responsiveness of psoriasis: a prospective study. J Am Acad Dermatol 1993; 28(5 Pt 1): 730-2. http://dx.doi.org/10.1016/0190-9622(93)70101-X DOI: https://doi.org/10.1016/0190-9622(93)70101-X
Poikolainen K, Reunala T, Karvonen J, Lauharanta J, Kärkkäinen P. Alcohol intake: a risk factor for psoriasis in young and middle aged men? BMJ 1990; 300(6727): 780-83. http://dx.doi.org/10.1136/bmj.300.6727.780 DOI: https://doi.org/10.1136/bmj.300.6727.780
Kirby B, Richards HL, Mason DL, Fortune DG, Main CJ, Griffiths CE. Alcohol consumption and psychological distress in patients with psoriasis. Br J Dermatol 2008; 158(1): 138-40. Epub 2007 Nov 10. Reference: Available from: http://www.ncbi.nlm.nih.gov/pubmed/17999698
Qureshi AA, Dominguez PL, Choi HK, Han J, Curhan G. Alcohol Intake and Risk of Incident Psoriasis in US Women, A Prospective Study. Arch Dermatol 2010; 146(12): 1364-69.
http://dx.doi:10.1001/archdermatol.2010.204 DOI: https://doi.org/10.1001/archdermatol.2010.204
Serwin AB, Wasowicz W, Gromadzinska J, Chodynicka Z. Selenium status in psoriasis and its relationship with alcohol consumption. Biol Trace Elem Res 2002; 89: 127-40. http://dx.doi.org/10.1385/BTER:89:2:127 DOI: https://doi.org/10.1385/BTER:89:2:127
PASI training [homepage on the Internet] [2009] Available from: http://www.pasitraining.com/about.html
Sharpe PC. Biochemical detection and monitoring of alcohol abuse and abstinence. Rev Article Ann Clin Biochem 2001; 38: 652-64. DOI: https://doi.org/10.1258/0004563011901064
Conigrave KM, Davies P, Haber P, Whitfield JB. Traditional markers of excessive alcohol use. Addiction 2003; 98(Suppl 2): 31-43. http://dx.doi.org/10.1046/j.1359-6357.2003.00581.x DOI: https://doi.org/10.1046/j.1359-6357.2003.00581.x
Ewing JA. Detecting alcoholism: the CAGE questionnaire. JAMA 1984; 252(14): 1905-907 http://dx.doi.org/10.1001/jama.1984.03350140051025 DOI: https://doi.org/10.1001/jama.252.14.1905
Bush B, Shaw S, Cleary P, Delbanco TL, Aronson MD. Screening for alcohol abuse using the CAGE questionnaire. Am J Med 1987; 82(2): 231-5. http://dx.doi.org/10.1016/0002-9343(87)90061-1 DOI: https://doi.org/10.1016/0002-9343(87)90061-1
Dhalla S, Kopec JA. The CAGE questionnaire for alcohol misuse: a review of reliability and validity studies. Clin Invest Med 2007; 30(1): 33-41. DOI: https://doi.org/10.25011/cim.v30i1.447
Facts and Details [homepage on the Internet] [Last updated March 2011] Available from: http://factsanddetails.com/world. php?itemid=1554&subcatid=347
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