Compositional Study of Polymer Blend PVA, Pectin, Sodium Alginate, and Gelatin Electrospun Nanofiber for Wound Dressing Application

Song  Jeng-Huang; Cynta Immanuela  Lamandasa; Chuan  Li

doi:10.6000/1929-5995.2025.14.01

Authors

Song Jeng-Huang Department of Mechanical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan https://orcid.org/0000-0002-6582-0339
Cynta Immanuela Lamandasa Department of Mechanical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan
Chuan Li Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, 11221, Taiwan

DOI:

https://doi.org/10.6000/1929-5995.2025.14.01

Keywords:

Nanofibers, polymer blend, electrospinning, wound healing

Abstract

Electrospun nanofibers are a biomaterial effective for wound healing due to their high surface area, tunable properties, and resemblance to the extracellular matrix. Nanofibers from the mixture of polymeric materials like gelatin, sodium alginate, pectin, and polyvinyl alcohol (PVA) were investigated in this study. Pectin, sodium alginate, and gelatin are selected for their nature of being applied as tissue carriers, and they have the properties of being biocompatible and biodegradable while inducing cell proliferation. Unfortunately, these polymers have some drawbacks: most of them have poor mechanical strength or poor processing ability through electrospinning. To enhance these properties, PVA was incorporated. The result showed that an optimal blend ratio of 20% PVA, 40% pectin, 25% sodium alginate, and 15% gelatin yielded a fibrous structure with an average diameter of the fibers equal to 174.82 ± 13 nm, surface tension of 33.29 mN/m, and viscosity at 7,378 cP, which facilitated the uniform fiber formation and a porous structure for enhanced gas exchange and moisture retention, significantly aiding wound healing.

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