Characterization of Phosphate Glass Reinforced Gelatin Blend Bioactive Composite Films

Kamol Dey; Poonam Alamgir; Shahnaz Parvin; Gulshana Mohol; Wafa Tonny; Mubarak A. Khan; Ruhul A. Khan

doi:10.6000/1929-5995.2014.03.03.2

Authors

Kamol Dey Department of Applied & Environmental Chemistry, Faculty of Science, University of Chittagong, Chittagong-4331, Bangladesh
Poonam Alamgir Department of Chemistry, Jahangirnagar University, Savar, Dhaka, Bangladesh
Shahnaz Parvin Department of Chemistry, Jahangirnagar University, Savar, Dhaka, Bangladesh
Gulshana Mohol Department of Chemistry, Jahangirnagar University, Savar, Dhaka, Bangladesh
Wafa Tonny Institute of Radiation and Polymer Technology, Bangladesh Atomic Energy Commission, Savar, Dhaka 1000, Bangladesh
Mubarak A. Khan Institute of Radiation and Polymer Technology, Bangladesh Atomic Energy Commission, Savar, Dhaka 1000, Bangladesh
Ruhul A. Khan Institute of Radiation and Polymer Technology, Bangladesh Atomic Energy Commission, Savar, Dhaka 1000, Bangladesh

DOI:

https://doi.org/10.6000/1929-5995.2014.03.03.2

Keywords:

Gelatin, phosphate glass, bioactive, composite films, stereo microscope.

Abstract

Bioactive composite films were prepared using bioresorbable phosphate glass powder and biodegradable polymer gelatin (G) through solution casting process. Biocompatible monomer, 2-hydroxyethyl methacrylate (HEMA) was used as the cross-linking agent and bioresorbable phosphate glass (PG) powder was used as reinforcement filler. The composite films were obtained at various ratios of G, PG and HEMA. The PG modified gelatin composite (PG/G) film was fabricated at a weight ratio of 12:88 while HEMA modified gelatin composite (HEMA/G) film at 50:50 ratio. On the other hand, hybrid gelatin composite film, containing both PG and HEMA, was obtained using a G/PG/HEMA ratio of 44:12:44. Incorporation of PG improved the mechanical properties of the composite films. Morphological property of the composite films was investigated by stereo microscope and it revealed that the composite films were porous in nature. The thermal behaviour of the films was studied using thermogravimetric analysis. Water uptake of the films was also performed.

References

Babu RP, O'Connor K, Seeram R. Current progress on bio-based polymers and their future trends. Prog Biomat 2013; 2: 1-16. http://www.progressbiomaterials.com/content/2/1/8 DOI: https://doi.org/10.1186/2194-0517-2-8

Chen Q. Biomaterials for bone tissue engineering. MK Danquah, RI Mahato (eds.), Emerging Trends in Cell and Gene Therapy 2013; 23: 563-94.

http://doi.org/10.1007/978-1-62703-417-3_23 DOI: https://doi.org/10.1007/978-1-62703-417-3_23

Sawaengsak C, Mori Y, Yamanishi K, Mitrevej A, Sinchaipanid N. Chitosan nanoparticle encapsulated hemagglutinin-split influenza virus mucosal vaccine. AAPS PharmSciTech 2013; 15: 317-25.

http://doi.org/10.1208/s12249-013-0058-7 DOI: https://doi.org/10.1208/s12249-013-0058-7

Wu CJ, Gaharwar AK, Schexnailder PJ, Schmidt G. Development of biomedical polymer-silicate nanocomposites: A materials science perspective. Materi 2010; 3: 2986-3005. http://dx.doi.org/10.3390/ma3052986 DOI: https://doi.org/10.3390/ma3052986

Martino VP, Pollet E, Avérous L. Novative biomaterials based on chitosan and poly(ε-caprolactone): Elaboration of porous structures. J Polym Environ 2011; 19: 819-26.

http://doi.org/10.1007/s10924-011-0354-9 DOI: https://doi.org/10.1007/s10924-011-0354-9

Park DH, Hwang SJ,Oh JM,Yang JH, Choy JH. Polymer–inorganic supramolecular nanohybrids for red, white, green, and blue applications. Prog Polym Sci 2013; 38: 1442- 86. http://dx.doi.org/10.1016/j.progpolymsci.2013.05.007 DOI: https://doi.org/10.1016/j.progpolymsci.2013.05.007

Liu X, Fan XD, Tang MF Nie Y. Synthesis and characterization of core-shell acrylate based latex and study of its reactive blends. Int J Mol Sci 2008; 9: 342-54. http://dx.doi.org/10.3390/ijms9030342 DOI: https://doi.org/10.3390/ijms9030342

Mathura V, Sharmab K. Structural, morphological and tensile study of CdS/Polystyrene (PS) nanocomposite. J Res Updates Polym Sci 2013; 2: 105-9. http://dx.doi.org/10.6000/1929-5995.2013.02.02.3 DOI: https://doi.org/10.6000/1929-5995.2013.02.02.3

Luo JQ, Yang B, Cheng GJ, Xia R, Su LF, Miao JB, Qian JS, Chen P. Preparation and characterization of nitrile butadiene rubber (NBR)/polyoxymethlene (POM) blends compatibilized by maleic anhydride grafted POM (MAH-g-POM). J Res Updates Polym Sci 2013; 2: 97-104. http://dx.doi.org/10.6000/1929-5995.2013.02.02.2 DOI: https://doi.org/10.6000/1929-5995.2013.02.02.2

Dey K, Alamgir P, Mohol G, Parvin S, Khan MA, Khan RA. Fabrication and thermo-mechanical characterization of HEMA treated UV photo-cured biodegradable chitosan film. J Res Updates Polym Sci 2014; 3: 86-96. http://dx.doi.org/10.6000/1929-5995.2014.03.02.3 DOI: https://doi.org/10.6000/1929-5995.2014.03.02.3

Lee WH, Park YD. Organic semiconductor/insulator polymer blends for high-performance organic transistors. Polym 2014; 6: 1057-73. http://dx.doi.org/10.3390/polym6041057 DOI: https://doi.org/10.3390/polym6041057

Chieng BW, Ibrahim NA, WMZY, Hussein MZ. Poly(lactic acid)/Poly(ethylene glycol) polymer nanocomposites: Effects of graphene nanoplatelets . Polym 2014: 6: 93-104. http://dx.doi.org/10.3390/polym6010093 DOI: https://doi.org/10.3390/polym6010093

Parsons AJ, Evans M, Rudd CD, Scotchford CA. Synthesis and degradation of sodium iron phosphate glasses and their in vitro cell response. J Biomed Mat Res, 2004; 71: 283-91.

http://doi.org/10.1002/jbm.a.30161 DOI: https://doi.org/10.1002/jbm.a.30161

Stepien R, Franczyk M, Pysz D, Kujawa I, Klimczak M, Buczynski R. Ytterbium-phosphate glass for microstructured fiber laser. Mater 2014; 7: 4723-38. http://dx.doi.org/10.3390/ma7064723 DOI: https://doi.org/10.3390/ma7064723

Ahmed I, Lewis M, Olsen I, Knowles JC. Phosphate glasses for tissue engineering: Part 1. Processing and characterisation of a ternary-based P2O5–CaO–Na2O glass system. J Biomat 2004; 25: 491-9.

http://doi.org/10.1016/S0142-9612(03)00546-5 DOI: https://doi.org/10.1016/S0142-9612(03)00546-5

Mavridis IM. Structural characterization of inorganic biomaterials. Biomedical Inorganic Polymers: Progress in Molecular and Subcellular Biology 2013; 54: 19-38.

http://doi.org/10.1007/978-3-642-41004-8_2 DOI: https://doi.org/10.1007/978-3-642-41004-8_2

Dorozhkin SV. Calcium orthophosphate-based biocom-posites and hybrid biomaterials. J Mater Sci 2009; 44: 2343-87.

http://doi.org/10.1007/s10853-008-3124-x DOI: https://doi.org/10.1007/s10853-008-3124-x

Fedotov AYu, Komlev VS, Smirnov VV, et al. Hybrid composite materials based on chitosan and gelatin and reinforced with hydroxyapatite for tissue engineering. J Inorg Mater App Res 2011; 2: 85-90.

http://doi.org/10.1134/S2075113311010072 DOI: https://doi.org/10.1134/S2075113311010072

Rose JB, Pacelli S, Haj AJE, et al. Gelatin-based materials in ocular tissue engineering. Mater 2014; 7: 3106-35. http://dx.doi.org/10.3390/ma7043106 DOI: https://doi.org/10.3390/ma7043106

Taokaew S, Seetabhawang S, Siripong P, Phisalaphong M. Biosynthesis and characterization of nanocellulose-gelatin films. Mater 2013; 6: 782-94. http://dx.doi.org/10.3390/ma6030782 DOI: https://doi.org/10.3390/ma6030782

Khan RA, Parsons AJ, Jones IA, Walker GS, Rudd CD. Surface treatment of phosphate glass fibers by using 2-hydroxyethyl methacrylate: Fabrication of poly(caprolactone) based composites. J App Poly Sci 2009; 111: 246-54.

http://doi.org/10.1002/app.29050 DOI: https://doi.org/10.1002/app.29050

Stol M, Smetana KJr, Korbelár P, Adam M. Poly (HEMA)-collagen composite as a biomaterial for hard tissue replacement. J Clinic Mater 1993; 13: 19-20.

http://doi.org/10.1016/0267-6605(93)90084-K DOI: https://doi.org/10.1016/0267-6605(93)90084-K

Georgiou G, Mathieu L, Pioletti DP, et al. Polylactic acid–phosphate glass composite foams as scaffolds for bone tissue engineering. J Biomed Mater Res Part B: Appl Biomat 2007; 80: 322-31.

http://doi.org/10.1002/jbm.b.30600 DOI: https://doi.org/10.1002/jbm.b.30600

Gul-E-Noor F, Khan MA, Ghoshal S, Mazid RA, Chowdhury SAM, Khan RA. Grafting of 2-ethylhexyl acrylate with urea onto gelatin film by gamma radiation. J Macromol Sci Part A: Pur App Chem 2009; 46: 615-24.

http://doi.org/10.1080/10601320902851926 DOI: https://doi.org/10.1080/10601320902851926

Sharmin N, Khan RA, Salmieri S, Dussault D, Lacroix M. Fabrication and characterization of biodegradable composite films made of using poly(caprolactone) reinforced with chitosan. J Polym Environ 2012; 20: 698-705. http://link.springer.com/article/10.1007/s10924-012-0431-8 DOI: https://doi.org/10.1007/s10924-012-0431-8

Yung KC, Zhu BL, Yue TM, Xie CS. Effect of the filler size and content on the thermomechanical properties of particulate aluminum nitride filled epoxy composites. J App Poly Sci 2010; 116: 225-36.

http://doi.org/10.1002/app.31431 DOI: https://doi.org/10.1002/app.31431

Ahmad MB, Lim JJ, Shameli K, Ibrahim NA, Tay MY. Synthesis of silver nanoparticles in chitosan, gelatin and chitosan/gelatin bionanocomposites by a chemical reducing agent and their characterization. Molecul 2011; 16: 7237-48. http://dx.doi.org/10.3390/molecules16097237 DOI: https://doi.org/10.3390/molecules16097237

Dey K, Khan RA, Sharmin N, Nahar S, Parsons AJ, Rudd CD. Effect of iron phosphate glass on the physico-mechanical properties of jute fabric-reinforced polypropylene-based composites. J Thermoplas Compo Mater 2011; 24: 695-711.

http://doi.org/10.1177/0892705711401848 DOI: https://doi.org/10.1177/0892705711401848

Rahman M, Dey K, Parvin F, et al. Preparation and characterization of gelatin-based PVA Film: Effect of gamma irradiation. J Polym Mater Polyme Biomat 2011; 60: 1056-69.

http://doi.org/10.1080/00914037.2010.551365 DOI: https://doi.org/10.1080/00914037.2010.551365