Cellulose-Based Hydrogels: Patent Analysis
DOI:
https://doi.org/10.6000/1929-5995.2022.11.03Keywords:
Cellulose, hydrogel, formulation, innovation, patent family, intellectual propertyAbstract
Background: Among biopolymers, cellulose and its derivatives are the most commonly used for hydrogel formulations. The innovation and improvement of cellulose-based hydrogels concerned the raw materials, synthesis and methods of preparation, formulations and fabrication processes, as well as applications.
Objectives: This study, in the form of patent analysis, presents the state by introducing what has been innovated and patented concerning cellulose-based hydrogels.
Methods: Three databases have been used in this study: the Patentscope, the Espacenet, and the Lens patent data set. A detailed analysis has been provided regarding publication dates, patent families, jurisdictions, inventors, applicants, owners, and patent classifications.
Results: A total of 8053 patent documents related to cellulose-based hydrogels have been published between 1965 and 2021. The United States leads the patent race in this sector, and the Massachusetts Institute of Technology is one of the top academic applicants.
Conclusion: Based on patent classifications, most patent documents are related to medicinal preparations characterized by special physical forms. More specifically, the classification concerns materials for prostheses or coating prostheses, including cellulose derivatives characterized by their function or physical properties, such as macromolecular gels, hydrogels, or hydrocolloids.
References
Song R, Murphy M, Li C, Ting K, Soo C, Zheng Z. Current development of biodegradable polymeric materials for biomedical applications. Drug Design, Development and Therapy 2018; 12: 3117-3145. https://doi.org/10.2147/DDDT.S165440 DOI: https://doi.org/10.2147/DDDT.S165440
Rubab Z, Muhammad Aslam M, Zafar I. Formulation, Characterization, Study of Swelling Kinetics and Network Parameters of Poly (MA-co-VA-co-AA) Terpolymeric Hydrogels with Various Concentrations of Acrylic Acid. Journal of Research Updates in Polymer Science 2013; 2: 142-152. DOI: https://doi.org/10.6000/1929-5995.2013.02.03.1
Weiss P, Fatimi A, Guicheux J, Vinatier C. Hydrogels for Cartilage Tissue Engineering. In Biomedical Applications of Hydrogels Handbook, Ottenbrite RM, Park K, Okano T, Eds, Springer New York: New York, NY, 2010; pp. 247-268. https://doi.org/10.1007/978-1-4419-5919-5_13 DOI: https://doi.org/10.1007/978-1-4419-5919-5_13
Fatimi A. Hydrogel-Based Bioinks for Three-Dimensional Bioprinting: Patent Analysis. Materials Proceedings 2021; 7: 3. https://doi.org/10.3390/IOCPS2021-11239 DOI: https://doi.org/10.3390/IOCPS2021-11239
Paula C, Carole F, Stéphane S, Monique L. Modification of Nanocrystalline Cellulose for Bioactive Loaded Films. Journal of Research Updates in Polymer Science 2014; 3: 122-135. https://doi.org/10.6000/1929-5995.2014.03.02.7 DOI: https://doi.org/10.6000/1929-5995.2014.03.02.7
Fatimi A, Axelos MAV, Tassin JF, Weiss P. Rheological Characterization of Self-Hardening Hydrogel for Tissue Engineering Applications: Gel Point Determination and Viscoelastic Properties. Macromolecular Symposia 2008; 266: 12-16. https://doi.org/10.1002/masy.200850603 DOI: https://doi.org/10.1002/masy.200850603
Fatimi A, Tassin JF, Quillard S, Axelos MA, Weiss P. The rheological properties of silated hydroxypropylmethylcellulose tissue engineering matrices. Biomaterials 2008; 29: 533-543. https://doi.org/10.1016/j.biomaterials.2007.10.032 DOI: https://doi.org/10.1016/j.biomaterials.2007.10.032
Fatimi A, Tassin JF, Turczyn R, Axelos MA, Weiss P. Gelation studies of a cellulose-based biohydrogel: the influence of pH, temperature and sterilization. Acta Biomaterialia 2009; 5: 3423-3432. https://doi.org/10.1016/j.actbio.2009.05.030 DOI: https://doi.org/10.1016/j.actbio.2009.05.030
Leone G, Fini M, Torricelli P, Giardino R, Barbucci R. An amidated carboxymethylcellulose hydrogel for cartilage regeneration. Journal of materials science. Materials in Medicine 2008; 19: 2873-2880. https://doi.org/10.1007/s10856-008-3412-7 DOI: https://doi.org/10.1007/s10856-008-3412-7
Vinatier C, Gauthier O, Fatimi A, Merceron C, Masson M, Moreau A, Moreau F, Fellah B, Weiss P, Guicheux J. An injectable cellulose-based hydrogel for the transfer of autologous nasal chondrocytes in articular cartilage defects. Biotechnol Bioeng 2009; 102: 1259-1267. https://doi.org/10.1002/bit.22137 DOI: https://doi.org/10.1002/bit.22137
Weiss P, Vinatier C, Sohier J, Fatimi A, Layrolle P, Demais V, Atmani H, Basle M-F, Guicheux J. Self-hardening hydrogel for bone tissue engineering. Macromolecular Symposia 2008; 266: 30-35. https://doi.org/10.1002/masy.200850606 DOI: https://doi.org/10.1002/masy.200850606
Weiss P, Fatimi A. Injectable composites for bone repair. In Biomedical Composites, Ambrosio L, Ed, Woodhead Publishing: Cambridge 2010; 2: pp. 255-275. https://doi.org/10.1533/9781845697372.2.255 DOI: https://doi.org/10.1533/9781845697372.2.255
De Ruyter PH, Winia JTB. Improvements in or relating to the manufacture of pellets of a hydrogel of carboxymethyl cellulose. Granted Patent: GB993675A, Great Britain, June 2, 1965.
World Intellectual Property Organization. The Patentscope. Available online: https://patentscope.wipo.int (accessed on February 10, 2022).
World Intellectual Property Organization. Patentscope fields definition. Available online: https://patentscope.wipo.int/search/en/help/fieldsHelp.jsf (accessed on February 10, 2022).
European Patent Office. Espacenet Patent Search. Available online: https://worldwide.espacenet.com, Version 1.29.0 (accessed on February 10, 2022).
Cambia Institute. The Lens Patent Data Set. Available online: https://www.lens.org, Version 8.2.1 (accessed on February 10, 2022).
European Patent Office. Espacenet Glossary. Available online: https://worldwide.espacenet.com/patent, Version 1.29.0 (accessed on February 10, 2022).
World Intellectual Property Organization. Handbook on industrial property information and documentation; WIPO: Geneva, Switzerland, 2013; p. 43.
Intellectual Property India. Jurisdiction of Patent Offices. Available online: https://ipindia.gov.in/jurisdiction-of-patent-offices.htm (accessed on February 10, 2022).
World Intellectual Property Organization. What is intellectual property? Frequently asked questions: Patents. Available online: https://www.wipo.int/patents/en/faq_patents.html (accessed on February 10, 2022).
World Intellectual Property Organization. IPC Publication. Available online: https://www.wipo.int/classifications/ipc/ipcpub, IPCPUB v9.1 (accessed on February 10, 2022).
Saga H, Saito H. Transparent cellulose hydrogel and process thereof. Granted Patent: EP0872275B1, Europe, March 20, 2002.
Li X, Wan W, Panchal CJ. Transparent bacterial cellulose nanocomposite hydrogels. Patent Application: WO2011079380A1, PCT, July 7, 2011.
Trexler MM, Graham JL, Breidenich JL, Maranchi JP, Patrone JB, Patchan MW, Elisseeff JH, Calderon-Colon X. Cellulose-based hydrogels and methods of making thereof. Granted Patent: US8871016B2, United States, October 28, 2014.
Nuopponen M, Kajanto I, Meriluoto A, Luukko K, Paasonen L. Method for reducing the viscosity of a nanofibrillar cellulose hydrogel. Granted Patent: US10307722B2, United States, June 4, 2019.
Zhong C, Zhao X, Zhang Y, Fazli W, Xie Y, Jia S. Cellulose antibacterial hydrogel and preparation method thereof. Patent Application: CN110804192A, China, February 18, 2020.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Policy for Journals/Articles with Open Access
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work
Policy for Journals / Manuscript with Paid Access
Authors who publish with this journal agree to the following terms:
- Publisher retain copyright .
- Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work .