Influence of Soybean Oil or Non-Soybean Oil Based Lipid Emulsions on Parenteral Nutrition Associated Liver Disease in Late Preterm and Term Infants

Authors

  • Rachel S.H. Wong Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Sydney, Australia
  • Karen Walker Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney, Sydney, Australia
  • Robert Halliday Grace Centre for Newborn Care, The Children’s Hospital at Westmead, Sydney, Australia
  • Amit Trivedi Grace Centre for Newborn Care, The Children’s Hospital at Westmead, Sydney, Australia

DOI:

https://doi.org/10.6000/1929-4247.2014.03.04.4

Keywords:

Parenteral Nutrition-Associated Liver Disease, lipid emulsion, fish-oil, soy, soybean, cholestasis, neonates, total parenteral nutrition, term infants.

Abstract

Background: Total parenteral nutrition (TPN) is a life-saving therapy given to neonates with intestinal failure. However, infants on long-term TPN may experience Parenteral Nutrition-Associated Liver Disease (PNALD). New formulations for lipid emulsions are purportedly better than the traditional soy-based lipid emulsions (SLE). Our primary objective was to determine the prevalence of PNALD in infants who received non-soybean-based lipid emulsions (NSLE) or SLE.

Methods: In this retrospective study, medical records of all infants admitted to a tertiary neonatal intensive care unitfrom 2004 to 2013 were reviewed. Late preterm (34 -36 weeks of gestation) and term infants who were on TPN for more than two weeks were included. Their demographic data and clinical variables were collected.

Results: 208 infants received SLE for more than two weeks. The prevalence rate of PNALD in those who received SLE was 21% while that of those who received the NSLE was 17%. No significant difference was found between the ‘Soy’ or ‘NonSoy’ subgroups (p = 0.315). Seventy infants received TPN for more than four weeks. The prevalence rate of PNALD in infants who received SLE and NSLE was 35% and 25% respectively. No significant statistical difference was found between the ‘Soy’ or ‘NonSoy’ subgroups (p = 0.132).

Conclusions: The type of lipid emulsion does not significantly influence the rate of PNALD in late preterm and term infants on long-term TPN.

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Published

2014-11-27

How to Cite

Wong, R. S., Walker, K., Halliday, R., & Trivedi, A. (2014). Influence of Soybean Oil or Non-Soybean Oil Based Lipid Emulsions on Parenteral Nutrition Associated Liver Disease in Late Preterm and Term Infants. International Journal of Child Health and Nutrition, 3(4), 179–184. https://doi.org/10.6000/1929-4247.2014.03.04.4

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