Anti-Inflammatory Activity of the Fruit Extract of Benincasa hispida

Deepak Kadam; Smita Lele

doi:10.6000/1929-5634.2014.03.04.6

Authors

Deepak Kadam Food Engineering and Technology Department, Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai 400019, India
Smita Lele Food Engineering and Technology Department, Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai 400019, India

DOI:

https://doi.org/10.6000/1929-5634.2014.03.04.6

Keywords:

Benincasa hispida, Phytochemicals, Anti-inflammatory, HRBC membrane stabilization, Carrageenan.

Abstract

Benincasa hispida (Ash gourd, family: Cucurbitaceae) is well known for its medicinal property. In the Ayurvedic system, it is used as a rejuvenating agent and in the treatment of nervous disorders. Methanolic and petroleum fruit extracts was subjected to evaluation of phytochemicals and acute oral toxicity study. Further, Anti-inflammatory activity was performed using human red blood cell (HRBC) membrane stabilization assay and carrageenan induced paw edema in rat. Oral administration of methanolic extract of concentration (350 mg/kg) significantly reduced the paw edema (P < 0.05) in a dose dependent manner as compared to carrageenan induced rats.

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