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Editor's Choice : Biomedical and Pharmaceutical Application of Fish Collagen and Gelatin: A Review
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Abstract: In last decade, more research has been conducted in order to find the better way for utilizing the wastes product generated from food processing industries. The increasing demand of industrial by-products is one of the main reasons for the conversion of these wastes into valuable products. Among the different valuable products from the waste, the extraction of collagen and gelatin could be a better way of utilizing the wastes, due to their effective applications in biomedical and pharmaceutical industries. The most abundant source of collagen and gelatin are land-based animals, such as cow and pig. However, the extraction of collagen and gelatin from non-mammalian sources such as fish has been high influences in current society due to some religious and disease transmission issues. Many studies have dealt with the extraction and functional properties of collagen and gelatin from fish wastes. The present work is a compilation of information on biomedical and pharmaceutical application of collagen and gelatin from fish processing wastes. Keywords: Collagen, gelatin, tissue engineering, wound healing, coatings.Download Full Article |
Editor's Choice : Inhibitory Effects of the Flower of Canadian Goldenrod (Solidago altissima L.) on Tumour Promotion Induced by 12-O-tetradecanoylphorbol-13-actete
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Abstract: Cancer prevention is an important issue in various healthcare fields; thus, we continue searching for potential useful compounds. This study focuses on the utilization of Canadian goldenrod, which is commonly seen growing on vacant land. Methanol extracts of the flower of Canadian goldenrod inhibited inflammation by 12-O-tetradecanoylphorbol-13-acetate (TPA) and inhibited promotion in the mouse skin two-stage carcinogenesis model. Five inhibitory compounds were isolated from the active fraction, and these compounds were identified as flavonoids; kaempferol (1), quercetin (2), kaempferol-3-O-rutinoside (3), querectin-3-O-rutinoside (4), and isorhamnetin-3-O-rutinoside (5). These compounds inhibited the inflammation induced by TPA, and the inhibitory effects were similar to indomethacin. Keywords: Canadian goldenrod, Solidago altissima, antitumour promotion, two-stage carcinogenesis, cancer prevention.Download Full Article |
Editor's Choice : Isovaleric Acidemia: A Novel Mutation with Mild Phenotype
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Abstract: Isovaleric Acidemia (IVA) is considered a severe metabolic disorder with significant morbidity and mortality. It is caused by deficiency of the enzyme Isovaleryl-CoA dehydrogenase (IVD). Early treatment with carnitine and glycine reduces the episodes of the severe metabolic crises. With the advent of neonatal screening, IVD deficiency has shown a spectrum of severity. We describe a novel homozygous mutation, R332L, in the IVD enzyme with a benign phenotype. Keywords: IVA, IVD, Isovalerylcarnitine, Isovalerylglycine, newborn screen. Download Full Article |
Editor's Choice : Nutraceuticals as Functional Foods
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Abstract: Nutraceuticals are considered to be fortified or enriched foods providing all the essential nutrients required for maintaining the optimal health. A numerous studies have suggested the potential association of nutraceuticals with diet and health. This article gives a brief review on the classification of nutraceuticals on the basis of the availability of the nutraceutical from the natural sources which is further being processed and proving its medical health benefits in the market. The review also summarizes about the functional nutraceuticals acting as dietary supplements, suggested to have the capacity to significantly contribute to the modulation of the complex mechanisms of disease pathology with a view being that they may be essential in optimizing in vivo defences and help in maintaining wellness. Nonetheless, several more clinical and biological studies are needed to support guidelines for the intake of nutraceutical for the prevention and treatment in specific diseases and its medical benefits. Keywords: Nutraceutical, Functional foods, Disease, Fortified foods, Health benefits.Download Full Article |
