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Abstract : Non-Parametric Test for Ordered Medians: The Jonckheere Terpstra Test
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Abstract: In clinical trials, sample size is usually lesser as compared to other epidemiological studies to make it more feasible and cost effective. Small sizes of such trials discourage the use of parametric test due to violation of the assumption under which they are applicable. Therefore, the use of nonparametric test is substantial in clinical trials to test two or more independent samples. The Kruskal-Wallis h test is an alternative to one-way ANOVA and can be used to identify significant differences among different populations. When we have several independent samples and assumed to be arranged orderly, Jonckheere Terpstra test is a best choice to compare population medians instead of means. For the application of Jonckheere Terpstra test the data from the study of cleaning methods for ultrasound probes are used. The Jonckheere Terpstra test is recommended over Kruskal-Wallis h test as it compares and provides significant difference between more than two population medians when they arranged in order. Therefore, the aim of this research paper was to explore the use and significance of Jonckheere-Terpstra test with the use of practical example. Keywords: Jonckheere Terpstra test, non parametric test, comparison of medians. Download Full Article |
Abstract : Using Propensity Score Matching in Clinical Investigations: A Discussion and Illustration
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Abstract: Propensity score matching is a useful tool to analyze observational data in clinical investigations, but it is often executed in an overly simplistic manner, failing to use the data in the best possible way. This review discusses current best practices in propensity score matching, outlining the method’s essential steps, including appropriate post-matching balance assessments and sensitivity analyses. These steps are summarized as eight key traits of a propensity matched study. Further, this review illustrates these traits through a case study examining the impact of access site in percutaneous coronary intervention (PCI) procedures on bleeding complications. Through propensity score matching, we find that bleeding occurs significantly less often with radial access procedures, though many other outcomes show no significant difference by access site, a finding that mirrors the results of randomized controlled trials. Lack of attention to methodological principles can result in results that are not biologically plausible. Keywords: Propensity Score Matching, Observational Data, Clinical Investigations. Download Full Article |
Abstract : Control Charts for Skewed Distributions: Johnson’s Distributions
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Abstract: In this study, some important issues regarding process capability and performance have been highlighted, particularly in case when the distribution of a process characteristic is non-normal. The process capability and performance analysis has become an inevitable step in quality management of modern industrial processes. Determination of the performance capability of a stable process using the standard process capability indices (Cp, Cpk) requires that the quality characteristics of the underlying process data should follow a normal distribution. Statistical Process Control charts widely used in industry and services by quality professionals require that the quality characteristic being monitored is normally distributed. If, in contrast, the distribution of this characteristic is not normal, any conclusion drawn from control charts on the stability of the process may be misleading and erroneous. In this paper, an alternative approach has been suggested that is based on the identification of the best distribution that would fit the data. Specifically, the Johnson distribution was used as a model to normalize real field data that showed departure from normality. Real field data from the construction industry was used as a case study to illustrate the proposed analysis. Keywords: Statistical Process Control, Shewhart control charts, non-normal data, Johnson System of distributions. Download Full Article |
Abstract : Editorial: The Reliability and Accuracy of Human Judgment
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Abstract: Editorial Download Full Article |
