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Abstract : Editorial: PET/CT for Cancer Diagnosis, Staging and Prognosis
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Editorial |
Abstract : 18F-FDG PET/CT Imaging in Detection of Intravascular Large B-Cell Lymphoma
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Abstract: Intravascular large B-cell lymphoma (IVLBCL) is a rare type of extranodal large B-cell lymphoma. Now, it remains a diagnostic challenge, because of non-specific findings on clinical, laboratory, and imaging studies. Here we present a case of an IVLBCL patient, who presented with fever of unknown origin and had skin involvement, that 18F-FDG PET/CT showed increased metabolism on systemic subcutaneous fat layer with a SUVmax of 1.29. After five courses of R-CHOP, 18F-FDG PET/CT showed disappearance of the diffuse FDG accumulation on systemic subcutaneous fat layer with a SUVmax of 0.55. These features make this case unique. Keywords: Lymphoma, Fever, 18F-FDG, PET/CT. Download Full Article |
Abstract : PET/CT and MRI in Evaluating Cervical Cancer
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Abstract: Positron emission tomography (PET)/computed tomography (CT) and magnetic resonance (MR) imaging are two most important imaging tools for evaluating cervical cancer in clinic. They have improved the accuracy of tumor staging and prognosis predicting in a large part. PET/CT is superior for lymph node (LN) status and metastasis to other imaging modalities. And it could differ among tumor types and grades according to maximum standardized uptake value (SUVmax). MRI is not sensitive to LN metastasis, but it shares the advantage of therapeutic response and recurrence evaluation with PET/CT. Recently, emerging functional imaging modality Diffusion-weighted imaging (DWI) has been showing its superiority on evaluation of cervical carcinoma as well. This article describes both advantages and limitations of MR imaging and PET/CT in evaluating cervical cancer, and reviews the current role of imaging techniques mentioned above. Keywords: Positron emission tomography, magnetic resonance,cervical cancer, staging, treatment response, recurrence. Download Full Article |
Abstract : 18F-FDG PET-CT in Cystic Tumors of the Pancreas
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Abstract: In order to plan treatment or follow-up of pancreatic cystic lesions, is crucial to distinguish benign from malignant cystic tumors with reliable, non-invasive methods. Despite evaluation with several preoperative investigations, a correct pathologic diagnosis rate does not exceed 68%. 2–[18F]–fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG PET-CT) has been found to be a highly sensitive and specific non-invasive procedure to detect malignancy in cystic tumors of the pancreas (CTP). The introduction of hybrid PET/CT scans allowed a more accurate localization of the foci of hypermetabolism. We reviewed 14 series (645 patients) with a CTP who underwent 18F-FDG PET-CT from 2001; four of these studies came from our group of investigators (226 patients). In the last studies, sensitivity in detecting malignancy ranged from 83 to 100% and specificity from 78 to 100%. 18F-FDG PET-CT for a long time was used only when conventional imaging was insufficient to rule out a cancer. In our experience, 18F-FDG PET-CT was found to be reliable to detect “cancer in situ” when no other investigations could detect it, so we stress the use of 18F-FDG PET-CT in the first assessment, as alternative to EUS with FNA, to exclude malignancy. We are lacking data about the use of 18F-FDG PET-CT and timing in the follow-up of patients (un)-operated. We suggest a regular use in the follow up of patients with intraductal papillary mucinous neoplasms (IPMN), due to their multifocality and to the high rate of extra-pancreatic cancers. Keywords: 18F-FDG PET/CT, standardized uptake value (SUV), pancreas, pancreatic cystic neoplasm, intraductal papillary mucinous neoplasm (IPMN). Download Full Article |
