JASCM
|
|
Abstract: Encapsulation of nonsteroidal or non-steroidal anti-inflammatory drugs (NSAID) in nanocarrier systems aims to enhance bioavailability and to decrease toxicity of these drugs and thus improve the efficacy of treatments. With this aim two types of nanoparticles were prepared and compared: lipid nanoparticles, made of cetyl palmitate and Miglyol 812 which were uncoated or coated with chitosan; or polymeric nanoparticles, made of poly (DL-lactic-co-glycolic acid) (PLGA) for which different emulsion stabilizers were also tested (poly (vinyl alcohol) (PVA), and Pluronic F68). Nanoparticles were characterized for drug content and for particle size, charge and morphology. The lipid matrix was analyzed regarding its crystallinity by differential scanning calorimetry (DSC). The size of the nanoparticles was measured by dynamic light scattering (DLS) which indicated a unimodal particle size distribution in all systems. Nanoparticles’ stability was confirmed by their highly negative surface charge in the case of polymeric and uncoated lipid nanoparticles, as analyzed by zeta potential measurements using electrophoretic light scattering (ELS). Lipid chitosan coated nanoparticles have also shown to be stable presenting highly positive surface charge. Results have further demonstrated that indomethacin is highly encapsulated regardless the type of particles. Morphological analysis by scanning electron microscopy has shown that the nanoparticles were smooth and spherical. The results gathered within the current study point to the conclusion that the proposed formulations provide nanoparticles of satisfactory quality to encapsulate indomethacin, which might be used to improve bioavailability of other NSAID in the treatment of inflammation. Keywords: NSAID, PLGA nanoparticles, nanostructured lipid carriers (NLC), encapsulation efficiency, dynamic and electrophoretic light scattering (DLS and ELS), differential scanning calorimetry (DSC), electron scanning microscopy (SEM). Download Full Article |
Acknowledgement | Journal of Applied Solution Chemistry and Modeling
Lifescience Global would like to appreciate and thank all the reviewers and authors for their rigorous and conscientious efforts for the Journal of Applied Solution Chemistry and Modeling. Below is the list of people who contributed towards the success of the journal during 2020.
|
Lifescience Global would like to appreciate and thank all the reviewers and authors for their rigorous and conscientious efforts for the Journal of Applied Solution Chemistry and Modeling. Below is the list of people who contributed towards the success of the journal during 2019.
|
Lifescience Global would like to appreciate and thank all the reviewers and authors for their rigorous and conscientious efforts for the Journal of Applied Solution Chemistry and Modeling. Below is the list of people who contributed towards the success of the journal during 2018.
|
Lifescience Global would like to appreciate and thank all the reviewers and authors for their rigorous and conscientious efforts for the Journal of Applied Solution Chemistry and Modeling. Below is the list of people who contributed towards the success of the journal during 2017.
|
Lifescience Global would like to appreciate and thank all the reviewers and authors for their rigorous and conscientious efforts for the Journal of Applied Solution Chemistry and Modeling. Below is the list of people who contributed towards the success of the journal during 2016.
|
Lifescience Global would like to appreciate and thank all the reviewers and authors for their rigorous and conscientious efforts for the Journal of Applied Solution Chemistry and Modeling. Below is the list of people who contributed towards the success of the journal during 2015.
|
Lifescience Global would like to appreciate and thank all the reviewers and authors for their rigorous and conscientious efforts for the Journal of Applied Solution Chemistry and Modeling. Below is the list of people who contributed towards the success of the journal during 2014.
|
Editor’s Choice | Journal of Applied Solution Chemistry and Modeling
|
The below articles have been selected by the Editor in Chief to be the top articles published in the journal. The topic, scientific quality and importance in the field where collectively considered while making this selection
|
||||||||||||||||
Volume 5, Number 1 |
||||||||||||||||
| Recent Advances on Design and Synthesis of Chiral Imidazolium Ionic Liquids and their Applications in Green Asymmetric Synthesis - Pages 3-20 Arijit Saha, Soumen Payra and Subhash Banerjee DOI: http://dx.doi.org/10.6000/1929-5030.2016.05.01.1
|
||||||||||||||||
| Volume 4, Number 4 |
||||||||||||||||
|
|
||||||||||||||||
| Volume 4, Number 3 |
||||||||||||||||
|
Thermodynamic Modeling of Chiral Compounds Solubility Using Correlative and Predictive Models- Pages 143-151 |
||||||||||||||||
| Volume 4, Number 2 |
||||||||||||||||
|
Preferential Solvation of the Antioxidant Agent Daidzein in some Aqueous Co-Solvent Mixtures according to IKBI and QLQC Methods - Pages 110-118 |
||||||||||||||||
| Volume 4, Number 1 |
||||||||||||||||
 Determination of pKa Values for Acrylic, Methacrylic and Itaconic Acids by 1H and 13C NMR in Deuterated Water - Pages 7-18Emma Lilia Ibarra-Montaño, Norma Rodríguez-Laguna, Aníbal Sánchez-Hernández and Alberto Rojas-Hernández DOI: http://dx.doi.org/10.6000/1929-5030.2015.04.01.2
|
||||||||||||||||
| Volume 3, Number 4 |
||||||||||||||||
| The Radical-Chain Addition to Double Molecular Bonds by the Nonbranched-Chain Mechanism: Low-Reactive Free Radicals Shortening Kinetic Chains - Pages 202-222 Michael M. Silaev DOI: http://dx.doi.org/10.6000/1929-5030.2014.03.04.3
|
||||||||||||||||
| Volume 3, Number 3 |
||||||||||||||||
| Excess Volume of Binary Mixtures of Water (Methanol or Ethanol) with an Ionic Liquid [EEIM][DEP] or [BEIM][DEP] at 1 atm and (293.15 to 333.15) K - Pages 152-158 Hong-Yan Song, Yin-Hui Gong, Xue-Mei Jiang and Chun-Xi Li DOI: http://dx.doi.org/10.6000/1929-5030.2014.03.03.2 Solubility Prediction of Paracetamol in N-Methyl-2-pyrrolidone + Ethanol + Water Mixtures at 25 - Pages 164-168 |
||||||||||||||||
| Volume 3, Number 2 |
||||||||||||||||
| Refractive Properties of Binary Mixtures Formed by an Isomer of Chlorobutane and Butyl Ethyl Ether - Pages 58-64 Diego F. Montaño, Héctor Artigas, M. Carmen López and Carlos Lafuente DOI: http://dx.doi.org/10.6000/1929-5030.2014.03.02.3 Preferential Solvation of Acetaminophen in Propylene Glycol + Water Co-Solvent Mixtures - Pages 65-73
|
||||||||||||||||
| Volume 3, Number 1 |
||||||||||||||||
| Anisotropic Properties of Mesogenic Surfactants with Ionic Liquid Core - Pages 8-14 Jinzhi Wu, Masanori Nata and Seiji Ujiie DOI: http://dx.doi.org/10.6000/1929-5030.2014.03.01.2 Separation and Recovery of SiC Particles Discharged from Silicon Wafer Production Process - Pages 32-38 |
||||||||||||||||
| Volume 2, Number 3 |
||||||||||||||||
| Potentiometric and Thermodynamic Studies of Some Azosulfoxine Derivatives and Their Metal Complexes - Pages 191-196 A.A. El-Bindary, A.Z. El-Sonbati, M.A. Diab and A.M. Barakat DOI: http://dx.doi.org/10.6000/1929-5030.2013.02.03.4 |
||||||||||||||||
| Volume 2, Number 2 |
||||||||||||||||
| Entropy-Enthalpy Compensation and its Significance – in Particular for Nanoscale Events - Pages 126-135 E.B. Starikov DOI: http://dx.doi.org/10.6000/1929-5030.2013.02.02.7 Design, Characterization and Evaluation of Metallic Nano Biocomposites of Neomycin - Pages 136-144 |
||||||||||||||||
| Volume 1, Number 2 |
||||||||||||||||
| Nanostructures and Thermal Properties of the Binary Mixture of DNA and a Zwitterionic Phospholipid in the Bulk - Pages 79-88 Ching-Mao Wu and Szu-Yin Lin DOI: http://dx.doi.org/10.6000/1929-5030.2012.01.02.1 |
Editor in Chief- Profile
Prof. Takashi Inui received his Master degree in science from Kwansei Gakuin University in 1989 and joined the International Research Laboratories of Ciba-Geigy Japan Ltd. (currently Novartis Pharma Ltd.). Therein he produced brilliant scientific achievements in pharmacological sciences, leading to receiving his Ph.D. degree from Kwansei Gakuin University in 1997. After leaving the company he completed 4-year postdoctoral training in the Department of Molecular Behavioral Biology at Osaka Bioscience Institute. In 2002, he accepted an associate professor position in the Department of Food and Nutrition at Tsu City College. In 2005, he joined Graduate School of Life and Environmental Sciences at Osaka Prefecture University as an associate professor, and has been a professor since 2011 to present.
Currently, his major research interest is to investigate correlation between the structure and function of a lipocalin family protein, which serves as a transporter of lipophilic low-molecular-weight compounds, by use of a variety of physicochemical techniques. As a goal of this research, he aims at development of a new drug delivery system to effectively utilize hydrophobic drugs that have been abandoned to develop in pharmaceutical companies. Besides, he is also interested in development of inhibitors of enzymes involved in nucleic acid biosynthesis in Trypanosoma brucei, protozoa causing African sleeping sickness.
Editorial Board
Editors-in-Chief:
Takashi Inui (Osaka Prefecture University, Sakai, Japan) Editors Profile
Editorial Board Members:
Merzougui Abdelkrim (University of Biskra, Biskra, Algeria)
Hamid Ashkenani (Shahid Bahonar University of Kerman, Kerman, Iran)
Tevfik Aysu (Yüzüncü Yil University, Van, Turkey)
Debbie C. Crans (Colorado State University, Fort Collins, CO, USA)
Hadji Djebar (MT University of Saida, Saida, Algeria)
William E. Acree (University of North Texas, Denton, TX, USA)
ORCID: https://orcid.org/0000-0002-1177-7419
Feng Yan (Soochow University, Suzhou, China)
Slobodan Gadžurić (University of Novi Sad, Novi Sad, Serbia)
Georgi Gochev (Max-Planck-Institute of Colloids and Interfaces (MPICI), Potsdam, Germany)
Mohammad Goodarzi (Vrije Universiteit Brussel-VUB, Brussels, Belgium)
Reza Hosseinzadeh (University of Tehran, Tehran, Iran)
Medhat Ahmed Abdel-Khalek Ibrahim (National Research Center, Giza, Egypt)
A. Ghasem Jouyban (Tabriz University of Medical Sciences, Tabriz, Iran)
Chi-wai Kan (The Hong Kong Polytechnic University, Kowloon, Hong Kong)
Carlos Lafuente (Universidad de Zaragoza, Zaragoza, Spain)
ORCID: https://orcid.org/0000-0003-3632-6822
Chunxi Li (Beijing University of Chemical Technology (BUCT), Beijing, China)
Marcela Raquel Longhi (Universidad Nacional de Córdoba, Córdoba, Argentina)
Luis Lugo (Universidade de Vigo, Vigo, Spain)
Fleming Martínez (Universidad Nacional de Colombia, Colombia)
Edward Muntean (University of Agricultural Sciences and Veterinary Medicine, Cluj Napoca, Romania)
Ime Bassey Obot (University of Uyo, Uyo, Nigeria)
Maria Elisabete C.D. Real Oliveira (University of Minho, Braga, Portugal)
Mihalj Poša (University of Novi Sad, Novi Sad, Serbia)
Tasnim Nisarahmed Shaikh (The M.S. University of Baroda, Baroda, India)
Evgeni B. Starikov (Chalmers University of Technology, Gothenburg, Sweden)
Shahid Bader Usmani (Mylan Pharmaceuticals ULC, Ontario, Canada)
Philip Verwimp (Université libre de Bruxelles, Bruxelles, Belgium)
Yue Wu (Virginia Commonwealth University, Richmond, VA, USA)
Chengliang Xiao (Soochow University, Suzhou, China)
Feng Yan (Soochow University, Suzhou, China)
| Malaysia |