Unveiling the Unpredicted and Uncontrolled Metastasis of Cancer Cells: A Minireview
Pages 75-87
Pravin K. Naoghare, Ajam Shekh, Amit Bafana, Kannan Krishnamurthi and Saravanadevi Sivanesan

DOI: http://dx.doi.org/10.6000/1929-2279.2016.05.03.1

Published: 23 August 2016

Abstract: Cancer as an historical disease is known to occur since several hundred years and still prevails till date as one of the most feared diseases. Its occurrence and/or progression are considered as the outcome of the series of accumulated ocogenic changes in the cell those transform it from benign to invasive or metastatic. It has been observed that most of the metastatic cancers are not curable and the available drugs focus on steadying the tumour growth to prevent further metastasis. Metastasis remains the cause of around 90% of the cancer deaths. Fundamental understanding of metastasis and recent advancements in metastasis driven cancer research may help to strengthen and bring in practice the new and advanced approaches for cancer treatment. In view of this, we review in detail the molecular mechanism of metastasis, problems in diagnosing and treating metastasis, and recent developments in cancer biology. Future efforts in order to unveil the unpredicted and uncontrolled metastasis of cancer cells have also been summarised.

Keywords: Cancer, Metastasis, Cancer stem cells, Cancer therapeutics, Cancer diagnosis.