jpans
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Abstract: Background: Breast cancer (BC) is the leading cause of cancer related deaths among women worldwide. Nutritional factors may account for the large variation in BC incidence around the world. Most studies have shown no link between dietary intakes and increased risk of BC. Objective: To evaluate the dietary intake of macro and some micronutrients among BC patients with respect to chemotherapy treatment. Methods: A total of 168 BC patients aged 20-70 years attending BC clinics at the Jordanian Royal Medical Services, Jordan were evaluated for dietary intake. The study design permitted to include 60 newly-diagnosed BC patients who were not exposed to any type of interventions and 108 recently-diagnosed BC patients (up to three months). Recently group member were sub-divided in two sub-groups to control exposure to chemotherapy. The Chemo group (have exposed to chemotherapy) and the non-chemo group (have exposed to other types of treatments interventions). Calculations were based on the computerized nutrient analysis program (the food processor nutrition and fitness analysis software (ESHA), version 10.6/.3, Salem, USA). Results: Energy, macronutrients and micronutrients intakes were not significantly different considering exposure to chemotherapy. However, they were less than recommended in all BC patients. Conclusion: The possible risk of dietary undernutrition among BC patients that need a careful monitoring, evaluation and managements care plan. Keywords: Breast Cancer, Vitamins, Minerals, Dietary intake, Chemotherapy and Jordanian. |
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Abstract: Zizyphus nummularia (Burm. F.) (Family: Rhamnaceae) used as a folk medicine. The study was designed to lay down the various physicochemical and phytochemical standards which will be helpful to ensure the purity, safety, and efficacy of this medicinal plant. In the lime light of fewer and less potent antioxidant extracts, it is screened for antioxidant potency also. All physico-chemical properties were found within the measurable amount. Preliminary phytochemical analysis confirmed the presence of alkaloids, flavonoids, tannins and steroids. Total phenolic content and flavonoid content was found to be 10.7±0.1 and 2.57±0.1 respectively. Extract also found to posses significant antioxidant activity which can be correlated with phenolic content. IC50 of 0.042 mg/mL was found during DPPH radical scavenging activity. 2.75 mmol AA/ mg extract was found to be as total antioxidant capacity along with a concentration of 383.4 µg/ml during reducing power activity. The study would help in the authentication stem bark useful for laying down pharmacopoeial standards and help in finding improved antioxidant agents from the extract. It is found to be posse’s significant antioxidant property, possibly by adsorbing and neutralizing free radicals. Keywords: Anti oxidant, Physicochemical, Phytochemical, Standardization, Zizyphus nummularia. |
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Abstract: The present study was aimed to create scientific insights that validate the traditional use of bark of ethanolic extract of S. cumini in thrombosis, CNS depression and in diarrheal cases. The CNS depressant activity was evaluated by observing the locomotor activity of the animals in the open field and forced swim methods at a dose of 200 and 400 mg/kg body weight and the anti-diarrheal activity was evaluated through castor oil induced method and charcoal induced GI motility tests. Finally thrombolytic activity assessment was done by employing Streptokinase as standard. In this study, among the five different concentrations 10 mg/ml showed maximum clot lysis that was 48.5%, whereas standard showed 51.05% lysis of clot. In case of open field test, the mean number of movement at 60 min were 20 and 31.11 at a dose of 200 and 400 mg/kg respectively. In case of castor oil induced method the above two doses of bark extract of S. cumini exhibited 23.07% and 36.67% of diarrheal inhibition compared to the standard Loperamide (5mg/kg) was 50%. For charcoal induced GI motility test, diarrheal inhibition was 23.07% and 36.67%. The present revealed that ethanolic bark extract of bark of S. cumini justify its traditional uses through good thrombolytic, CNS depressant and anti-diarrheal activity. Keywords: Syzygium cumini, Thrombolytic, CNS depressant, Anti-diarrhoeal. |
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Abstract: Background: Oxidative stress has been shown to play an imperative role in copious disease pathology. Plants are acquaintances of mankind and mainstay for the treatment of oxidative stress linked disorders. Therefore, the objective of the existing study was to assess the phytochemical contents and antioxidant activity of crude methanol extract (CME), n-hexane (NHF), chloroform (CLF), ethyl acetate (EAF) and aqueous (AQF) fractions of Syngonium podophyllum (S. podophyllum) Schott stems. Methods: The S. podophyllum Schott stems extract and its fractions were subjected to phytochemical analysis to detect the presence of alkaloids, carbohydrates, saponins, tannins, resins, flavonoids and steroids. The antioxidant profile was determined by total antioxidant activity (TAA), reducing power activity (RPA) and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity tests and correlated with the estimation of total flavonoid content (TFC). Results: In CME and its fractions of S. podophyllum Schott stems all of the tested phytoconstituents (alkaloids, tannins, resins, flavonoids and steroids) were detected at various concentration except carbohydrates and saponins. In TAA test, highest absorbance (2.18 nm) which is a measure of high antioxidant activity was reported in CME compared to remaining fractions. Likely in RPA test with respect to all fractions similar denouements were found for CME (3.29 nm). In case of DPPH scavenging test, the CME showed highest scavenging activity (77.89 %) having IC50 of 41.02 μg/ml (P < 0.05) compared to remaining fractions. The antioxidant activity is possibly due to the highest TFC (7.45 mg of GAE/g of dried extract) reported in CME compared to existing fractions. Conclusion: The aforementioned outcomes recommend that CME of S. podophyllum Schott stems can be a possible cradle of plant-derived natural antioxidant and can be used to avert diseases linked with free radicals. Keywords: Syngonium podophyllum, Phytochemical Screening, Antioxidant Profile, Phenols, Oxidative Stress. |
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Abstract: Objective: Methylsulfonylmethane (MSM) is a naturally occurring nutrient composed of sulfur, oxygen and methyl groups. MSM may have anti-inflammatory and free radical scavenging activity. The present work was done to investigate the possible cure effect of methylsulfonylmethane on glycerol-induced acute renal failure (ARF) in rats. Methodes: After water deprivation, a kidney injury was induced in rats by intramuscular administration of glycerol 10 mL/kg (50% vol./vol. in saline). Several parameters including macroscopic score, histopathological and biochemical were determined to assess the degree of treatment. Results: Results showed that MSM decreased macroscopic and microscopic kidney’s injury scores caused by glycerol. MSM also significantly reduced urea and creatinine levels compared to glycerol-induced ARF group. Conclusion: MSM as a natural product has a curing effect against glycerol-induced myoglobinuria. Keywords: Methylsulfonylmethane (MSM), Acute renal failure, Myoglobinuria. |