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Abstract : Study of Cardiac Features in Adults with Down Syndrome
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Abstract: Down Syndrome (DS) has a significant impact on the development of many tissues, most notably in the heart and in the brain. According to the clinical need to better investigate these aspects, the main aim of this study was to make an overview on the cardiac features in adult individuals with DS. The following data of 37 individuals with DS (range: 18-60 years) were collected and analysed: age, gender, height, weight, waist to height ratio (WHER), smoking history and cardiac parameters (heart rate and blood pressure), blood glucose level or glycaemia, cholesterol (total, high-density lipoprotein – HDL - and low-density lipoprotein - LDL - cholesterol) and triglycerides. In addition, their gait pattern were quantified with 3D Gait Analysis. BMI, WHER and cholesterol HDL results were above the upper limits of the recommended range in people with DS; on the contrary, blood pressure, heart rate, glycaemia, cholesterol-LDL and triglycerides were within the recommended range. Comparing males and females in the DS group, the females showed statistically different values for cholesterol-total, and triglycerides values, with lower values in comparison to males. In motor performance, people with DS presented abnormal gait patterns. Some significant correlations were found: age with LDL, WHER with weight and BMI, systolic with diastolic blood pressure, total cholesterol with LDL and triglycerides. Our results showed that adults with DS suffer from a high prevalence of physical disorders, including overweight and obesity, and abnormal cholesterol values, together with abnormal gait pattern. Keywords: Down Syndrome, cardiac features, gait, intellectual disability, rehabilitation. |
Abstract : Morphosyntactic Development and Implicit Learning in Down Syndrome and Related Conditions
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Abstract: Implicit learning of morphosyntax is attracting much interest in psycholinguistics. Limited data are available from experimental studies in people with cognitive handicap. The paper presents and discusses central aspects of the implicit learning model as it applies to morphosyntactic development in typical children and children and adolescents with cognitive handicap. Several possible reasons for the delays and difficulties usually observed in the latter are examined. Suggestions are made for further research and language intervention in cognitive handicap. Keywords: Attentional focus, associative processes, mental representation, relational semantics, morphosyntactic patterns. |
Abstract : Meynert’s Nucleus Complex White Matter Abnormalities in Autism Spectrum Disorders: An MRI Study
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Abstract: Introduction: Cholinergic dysfunction has been proposed to play a role in autistic symtomatology. However, to date, its structural correlates are poorly understood. Methods: Twenty-five low-functioning, non-verbal males with Autism Spectrum Disorders (ASD) and 25 controls were enrolled in the study. All underwent MR T1-weighted 3D Structural Imaging and Diffusion Tensor Imaging. Grey and white matter components of the Meynert’s Nucleus Complex were then identified on MR images, and both grey matter density and white matter mean Fractional Anisotropy in the Meynert’s Nucleus region of interest were quantified for each subject. Non-verbal IQ was assessed in all subjects with ASD. Results: We showed reduced white matter Fractional Anisotropy in the bundles surrounding the Meynert’s Nucleus in ASD subjects compared to controls. Fractional Anisotropy in these bundles was positively associated with non-verbal IQ, independently from whole brain white matter mean Fractional Anisotropy. ASD subjects did not show significant abnormalities in Meynert’s Nucleus grey matter density. Conclusions: Our findings suggest that white matter abnormalities in the Meynert’s Nucleus might be involved in the cholinergic deficits of ASD. Keywords: Autism, cholinergic system, Meynert’s nucleus, diffusion tensor imaging, white matter.Download Full Article |
Abstract : Atypical Eating Behaviors Identified in Children with Fetal Alcohol Spectrum Disorders, Aged 3 to 5 Years, Using the Children’s Eating Behavior Questionnaire in a Caregiver-Reported Online Survey
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Abstract: Background: Children with fetal alcohol spectrum disorders (FASDs), aged 3 to 5 years, have physical, behavioral, and functional problems. Because of alcohol-related deficits, children with FASDs are at risk for malnutrition; yet, little is known about how FASD affects eating behavior and nutrition. Aim: The purpose of this study was to identify atypical eating behavior in children with FASDs, aged 3 to 5 years, and their associations with socio-demographic characteristics. Method: This descriptive cross-sectional study gathered data from a caregiver-reported online survey targeting the eating behavior of preschool-aged children with FASDs. The survey included the Children’s Eating Behavior Questionnaire (CEBQ) and a socio-demographic questionnaire. Participants/Setting: Seventy-four caregivers qualified for the study with nine having two children with FASDs. Responses to survey questions varied since caregivers had permission to omit any question. Results: Significant differences were found between the preschool-aged children with FASDs and Wardle’s published normative sample by gender and age. Compared to reported norms, study children scored higher in Desire to Drink, Food Responsiveness, Emotional Overeating, and Food Fussiness, and lower in Enjoyment of Food. Regarding socio-demographic characteristics, there was greater Enjoyment of Food with larger families and Food Avoidance with college-educated caregivers. Conclusion: Children with FASDs, aged 3 to 5 years, have atypical eating behaviors characteristic of maladaptive appetites, overeating under stress, selective eating, slowness in eating, and an excessive need for drinks, in comparison with a published normative sample. Keywords: Fetal alcohol syndrome, prenatal alcohol exposure, atypical eating behavior, preschool-aged children, and Children’s Eating Behavior Questionnaire.Download Full Article |
